A New 3D Virtual Reality-based Upper Limb Training to Improve Dexterity in Parkinson's Disease

Not Applicable

Recruiting

• Conditions: Parkinson Disease
• Interventions: Other: virtual reality control training; Other: virtual reality upper limb hand training

• Registration Number: NCT05965661
• Lead Sponsor: Luzerner Kantonsspital

Brief Summary

We investigate the impact of a 4-week virtual reality-based upper limb training in Parkinson's disease. The benefits on dexterity of this training program will be evaluated.

For these purposes, a randomised, two arm, single assessor blind, parallel design with a monocentric, study setup will be performed.

Detailed Description

Patients with Parkinson's disease (PD) suffer from significantly decreased coordination and have difficulties with precise hand/finger movements during the performance of both basic activities of daily living (ADL), such as dressing, grooming as well as higher ADL, such as cooking, shopping and regular medication intake. These difficulties further add to the burden of the disease, leading to reduced quality of life (QoL). A relatively new, but rapidly growing aspect of training in PD neurorehabilitation offers virtual reality (VR). We explore the effects of a VR-based upper limb hand training compared to a VR control training, which is less specific for dexterity. Moreover, we examine the effetcs of the trainings on upper limb related ADL, and therefore the impact on QoL in patients with PD.

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-13
• Study Start: 2023-07-19
• Study First Submitted QC: 2023-07-20
• Last Update Submitted: 2023-07-20
• Study First Posted: 2023-07-28
• Last Update Posted: 2023-07-28
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with confirmed PD, according to UK Brain bank Criteria
• Hoehn & Yahr Stadium I to IV
• Age 40 to 99 years
• written and signed informed consent
• self-reported dexterous difficulties

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Exclusion Criteria

• MoCA <21/30
• psychiatric disease
• participation on other interventional trials
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• severe visual impairment

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Virtual reality control training	virtual reality control training	The PD patients randomized in the control group will receive virtual reality control training.
Virtual reality upper limb hand training	virtual reality upper limb hand training	The PD patients randomized in the experimental group will receive virtual reality upper limb hand training.

Primary Outcome Measures

Name	Time	Method
fine finger movements	4 weeks	Coin rotation task (CRT): The CRT measures fine coordinated finger movements and is a suitable and valid dexterity test in patients with PD. The seconds for 20 halfturns will be measured.

Secondary Outcome Measures

Name	Time	Method
self-reported dexterity related problems in daily living	4 weeks	Dexterity Questionnaire 24 (DextQ-24): This questionnaire is a standardized patient self-rated outcome measure (PROM) for evaluating dexterity related ADL in PD. score range 24-96, higher scores mean more dexterity problems.
self-reported problems in quality of life	4 weeks	Parkinson's Disease Questionnaire (PDQ-39): This questionnaire is a standardized patient self-rated outcome measure (PROM) for evaluating QOL in PD. range 0-156, higher values mean more problems.
motor function	4 weeks	MDS-Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS III): It evaluates motor aspects of Parkinson's disease
hand dexterity	4 weeks	Nine Hole Peg test (9-HPT): The 9-HPT is a standardized, well established, and reliable measure of hand dexterity in patients with PD. seconds will be measured.
grip strenght	4 weeks	The handheld JAMAR dynamometer measures the grip strength. kg will be measured.

Trial Locations

Locations (1)

Luzerner Kantonsspital; 🇨🇭 Lucerne, Switzerland