Effects of postprandial hyperglycemia on aortic elasticity in impaired glucose tolerance and diabetes mellitus type 2

Recruiting

• Conditions: elasticity aorta; pulse wave velocity; 10018424; 10003216

• Registration Number: NL-OMON34650
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

For all: Age: 18-65 years, informed consent.
Patients with T2DM: untreated or treated with oral glucose lowering agents
HbA1c < 8.5%
Subjects with impaired fasting glucose: fasting glucose 5.6-6.9 mmol/l

Exclusion Criteria

Healthy controls and impaired glucose tolerance: grade 2 or 3 hypertension at screening (ESC guidelines); use of glucose lowering mediaction/ statins or antihypertensives; any significant chronic disease; smoking; contra-indications MRI
Patients with type 2 diabetes: tension: >140/90 mmHg; use of insulin/ thiazolidinediones/ smoking/ contra-indications MRI

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pulse Wave Velocity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Heart Rate variability<br />Glucose and insulin levels<br />Cardiac function</p>