Het effect van een suikerbelasting op de vaatwand van de aorta.
Recruiting
- Conditions
- Diabetes mellitus 2 (ouderdomssuikerziekte)Aortic elasticity (flexibiliteit van de aorta)
- Registration Number
- NL-OMON24498
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
1. Impaired fasting glucose (fasting glucose 5.6-6.9 mmol/l);
2. Age 18-75 years;
Exclusion Criteria
1. Fasting plasma glucose =/. 7 mmol/l or previously diagnosed T2DM;
2. Grade 2 or 3 hypertension at screening according to ESC guidelines 2007;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Magnetic resonance imaging: Aortic pulse wave velocity;<br /><br>2. Heart rate variability.
- Secondary Outcome Measures
Name Time Method 1. Heart dimensions: End-diastolic volume, end systolic volume, LV mass, LV mass index, LVMI/EDVI;<br /><br>2. Heart function: Systolic function (stroke volume, ejection fraction, cardiac output, cardiac index, peak ejection rate), diastolic function (early peak filling rate E, early deceleration peak, atrial peak filling rate A, E/A ratio, peak mitral annulus longitudinal motion, MR estimate of LV filling pressure);<br /><br>3. Body fat distribution;<br /><br>4. Glucose and insulin levels.