eft Ventricular Thrombus Formation after Acute Myocardial Infarction - a randomized multi-center trial comparing 2 different anti-thrombotic regimens - LV thrombus after AMI

Academisch Medisch Centrum0 个研究点目标入组 650 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•1.Suspected LV thrombus on echocardiography or routine MRI ;2.Ongoing treatment with dual antiplatelet therapy (e.g. ASA and clopidogrel) at the time of;randomization

•The following exclusion criteria are applied:;1 Younger than 18 ;2 Clinically or hemodynamically unstable;3 Treatment with vitamin K antagonist prior to PCI or other expected indication for vitamin K antagonist treatment (e.g. atrium fibrillation) within the next 6 months;4 Previous stroke or transient ischemic attack ;5 Scheduled for major surgery (including CABG) during the course of the study;6 Active bleeding or high risk for bleeding contraindicating treatment with vitamin K antagonists;7 Contra-indication for vitamin K treatment;8 Chronic treatment with NSAIDs or COX-2 inhibitors for more than 4 days per week anticipated to continue during the study;9 Congenital cardiac disease;10 Presence of supraventricular or ventricular arrhythmias;11 Expected candidate for ICD implantation with the next 6 months;12 Severe renal impairment (estimated glomerular filtration rate (eGFR) <= 30mL/min);13 Known or symptomatic brain disease (e.g. brain tumor);14 Women who are pregnant. ;15 Any contraindication for Contrast-Enhanced Magnetic Resonance Imaging i.e.:;• pacemaker;• cerebrovascular clips ;• known contrast allergy;• claustrophobia;16 Follow-up impossible (no fixed abode, etc)

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