eft Ventricular Thrombus Formation after Acute Myocardial Infarction - a randomized multi-center trial comparing 2 different anti-thrombotic regimens - LV thrombus after AMI

Academic Medical Center0 个研究点开始时间: 2011年11月23日最近更新: 2012年3月19日

试验速览

暂无简介。

•1.Suspected LV thrombus on echocardiography or routine MRI
•2.Ongoing treatment with dual antiplatelet therapy (e.g. ASA and clopidogrel) at the time of
•randomization
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 150
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 100

•The following exclusion criteria are applied:
•1Younger than 18
•2Clinically or hemodynamically unstable
•3Treatment with vitamin K antagonist prior to PCI or other expected indication for vitamin K antagonist treatment (e.g. atrium fibrillation) within the next 6 months
•4Previous stroke or transient ischemic attack
•5Scheduled for major surgery (including CABG) during the course of the study
•6Active bleeding or high risk for bleeding contraindicating treatment with vitamin K antagonists
•7Contra-indication for vitamin K treatment
•8Chronic treatment with NSAIDs or COX-2 inhibitors for more than 4 days per week anticipated to continue during the study
•9Congenital cardiac disease
•10Presence of supraventricular or ventricular arrhythmias
•11Expected candidate for ICD implantation with the next 6 months
•12Severe renal impairment (estimated CrCl calculated by Cockcroft-Gault equation
•= 30mL/min)
•13Known or symptomatic brain disease (e.g. brain tumor)
•14Women who are pregnant.
•15Any contraindication for Contrast-Enhanced Magnetic Resonance Imaging i.e.:
•cerebrovascular clips
•known contrast allergy
•claustrophobia
•16Follow-up impossible (no fixed abode, etc)

发起方

Academic Medical Center