Comparative placebo controlled study of dexamethasone and Magnesium sulphate in preventing post operative sore throat Following endotracheal intubation
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To compare the effect of Dexamethasone versus Magnesium
研究概览
简要总结
Introduction: Post-operative sore throat is a common complication following endotracheal intubation, impacting patient comfort and recovery. Dexamethasone and magnesium sulfate have been studied for their potential to mitigate this issue, yet their comparative effectiveness against a placebo remains to be comprehensively evaluated.
Objective: This study aims to compare the efficacy of dexamethasone and magnesium sulfate, each against a placebo, in preventing post-operative sore throat following endotracheal intubation.
Methods: A randomized, placebo-controlled trial will be conducted among patients undergoing surgeries requiring endotracheal intubation. Participants will be randomly assigned to receive dexamethasone, magnesium sulfate, or placebo preoperatively. Post-operative sore throat severity will be assessed using a standardized scoring system, along with monitoring of adverse effects.
Outcome: This study will provide effectiveness of dexamethasone and magnesium sulfate compared to placebo in preventing post-operative sore throat, contributing to optimized perioperative management strategies.
Conclusion: Findings from this study will inform clinical practice regarding the use of different interventions to reduce post-operative sore throat incidence following endotracheal intubation, potentially improving patient outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I & II Modified Mallampatti Score 1-2.
排除标准
- •1.Patients who needed more than two attempts at endotracheal intubation and use of bougie and styllete
- •Patients with history of sore throat
- •Long term anti-inflammatory analgesic medications
- •Patients who have undergone insertion of devices which stimulate oral cavity, larynx, pharynx like nasogastric tube
- •Obese, diabetic, pregnant patients.
结局指标
主要结局
To compare the effect of Dexamethasone versus Magnesium
时间窗: at the time of start of surgery, 4 hours, 8 hours and 24 hours
sulphate against placebo in preventing POST following endotracheal intubation
时间窗: at the time of start of surgery, 4 hours, 8 hours and 24 hours
次要结局
- To Compare the frequency and severity of post operative sore throat among the patients in(each group)
研究者
Dr Chiteshwar Walia
Sri Guru Ram Das Institute of Medical Sciences and Research