NCT06925828进行中（未招募）不适用
Application of in Vivo Splitting Technique of Brain-dead Donor Liver in Adult Liver Transplantation
Ningbo Medical Center Lihuili Hospital1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2021年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
The feasibility of split liver transplantation (SLT) remains controversial. This study aimed to evaluate the outcomes of SLT in adult recipients and to identify specific areas of improvements. A retrospective analysis was conducted on adults who underwent full size SLT between January 2021 and December 2023. The short-term outcomes of these patients who underwent SLT were compared with those of patients who underwent whole liver transplantation (WLT) during the same period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For the donor graft:
- •age of 18-60 years;
- •BMI of 19-28 kg/m2;
- •hemodynamic stability or use of a single vasoactive drug with a small dosage (norepinephrine ≤ 0.1 μg/kg/min or dopamine ≤ 5 μg/kg/min);
- •liver steatosis ≤ 10%;
- •liver functional indicators (ALT, AST, total bilirubin quantification) ≤ 3 times the normal value;
- •blood sodium ≤ 160 mmol/L;
- •For the SLT recipients
- •Patients who had registered in the China Organ Transplant Response Systems.
- •Initial liver transplantation.
- •Graft-to-Recipient Weight Ratio (GRWR) ≥ 1%.
排除标准
- •For the donor graft
- •uncontrollable infection
- •significant vascular and biliary variation.
- •For the recipients
- •Severe portal hypertension.
- •Significant vascular variation.
结局指标
主要结局
Overall survival
时间窗: 2021.01.01-2025.12.31
the overall survival of liver transplant recipient during study period
次要结局
- Postoperative complications(2021.01.01-2025.12.31)
研究者
lucaide
Professor
Ningbo Medical Center Lihuili Hospital
研究点 (1)
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