Efficacy of Preoperative Intravenous Tranexamic Acid Before Caesarean Section in Placenta Previa
- Conditions
- intraoperative blood loss in pregnant woman undergoes caesarean section due to placenta previaKeyword: Tranexamic acid, preoperative, placenta previa, intraoperative blood loss, caesarean section
- Registration Number
- TCTR20220930003
- Lead Sponsor
- none
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 60
1. All pregnant woman with placenta previa diagnosed by transabdominal or transvaginal ultrasound(if not clearly by TAS) confirmed at GA 28 week by obstetricians
3.undergoing caesarean delivery for placenta previa include elective c/s at term (37+ week) or emergency c/s due to placenta previa
4.Repeat ultrasound confirm before caesarean section
5.Age > 18 year and already informed consent
1. Allergic patient to transamine
2. Undergo caesarean section due to placenta previa before GA 28 week
3. follow up by ultrasound during antenatal care and diagnosis was changed
4. Patient with showed any sign of adherent placenta on ultrasound
5. Patient with active cardiac, hepatic, renal disease
6. patient with risk factor for VTE such as prior VTE, thrombophilia disease**, hematologic cancer, immobilize patient, first degree relative history of VTE, morbid obesity BMI>40
7.Underlying disease of Coagulopathy, thrombocytopenia or on anticoagulant
8. patient cannot make decision
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method intraoperative blood loss intraoperative intraoperative blood loss measured by amount of blood in suction add with diffrent weight between soaked gauze and dry gauze
- Secondary Outcome Measures
Name Time Method incidence of PPH 24 hour postpartum measured blood loss 24 hr postpartum more than 1000 ml