Mechanisms of Exercise-Induced Hypoalgesia

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Positive Expectations Instructional Set; Other: Negative Expectations Instructional Set

• Registration Number: NCT06050889
• Lead Sponsor: University of Central Florida

Brief Summary

Exercise-Induced Hypoalgesia (EIH) is a lessening of pain sensitivity in response to an acute bout of exercise. Limited research has examined the effects of expectations on EIH during a dynamic resistance training during different intensities. Therefore, the purpose of this study is to examine the effects of positive and negative expectations on EIH.

Detailed Description

Individuals who meet the eligibility criteria and consent to participate will attend one testing session that is approximately one hour. Baseline Pressure Pain Threshold will be measured followed by random assignment to one of four study arms.

Study Timeline

• Study First Submitted: 2023-09-15
• Study First Submitted QC: 2023-09-15
• Study First Posted: 2023-09-22
• Study Start: 2023-11-14
• Status Verified: 2024-04
• Primary Completion: 2024-04-19
• Study Completion: 2024-04-19
• Last Update Submitted: 2024-04-19
• Last Update Posted: 2024-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Pain Free

Exclusion Criteria

• Non-English speaking
• Regular use of prescription pain medications
• Current or history of chronic pain condition
• Currently taking blood-thinning medication
• Any blood clotting disorder, such as hemophilia
• Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
• Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
• Not have had Surgery, injury, or fracture within the past 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High Intensity Exercise	Positive Expectations Instructional Set	Participants will complete an upper body resistance exercise until they report a high fatigue level.
Low Intensity Exercise	Negative Expectations Instructional Set	Participants will complete an upper body resistance exercise until they report a low fatigue level.
High Intensity Exercise	Negative Expectations Instructional Set	Participants will complete an upper body resistance exercise until they report a high fatigue level.
Low Intensity Exercise	Positive Expectations Instructional Set	Participants will complete an upper body resistance exercise until they report a low fatigue level.

Primary Outcome Measures

Name	Time	Method
Pressure Pain Threshold	Change from baseline immediately after exercise	Pressure Pain Threshold will be applied with a digital algometer before and after the exercise intervention.

Trial Locations

Locations (1)

University of Central Florida; 🇺🇸 Orlando, Florida, United States