The Effect of Exercises of Different Intensity Applied After Total Knee Arthroplasty on Exercise-Induced Hypoalgesia

Not Applicable

Completed

• Conditions: Pain, Acute; Knee Osteoarthritis
• Interventions: Behavioral: High Intensity Exercises Program; Behavioral: Low Intensity Exercises Program

• Registration Number: NCT05781230
• Lead Sponsor: Hacettepe University

Brief Summary

The aim of this study was to investigate whether exercise-induced hypoalgesia (EIH) is present following exercise in patient after total knee arthroplasty (TKA) and if so, if it changes with exercise intensity. A repeated measures and single-blinded randomized study were done. Thirty-eight patients 24 hours after TKA were randomly assigned to either low intensity exercises (LIE) group or high intensity exercises (HIE) group. An exercise programs lasted for five days during the hospitalization period. Pain severity was assessed by Visual Analog Scale (VAS) (0-10 mm). Pressure pain thresholds (PPTs) were measured over quadriceps and biceps brachii and muscles immediately before and after exercise.

Detailed Description

Background: The aim of this study was to investigate whether exercise-induced hypoalgesia (EIH) is present following exercise in patient after total knee arthroplasty (TKA) and if so, if it changes with exercise intensity.

Methods : A repeated measures and single-blinded randomized study were done. Thirty-eight patients 24 hours after TKA were randomly assigned to either low intensity exercises (LIE) group or high intensity exercises (HIE) group. An exercise programs lasted for five days during the hospitalization period. Pain severity was assessed by Visual Analog Scale (VAS) (0-10 mm). Pressure pain thresholds (PPTs) were measured over quadriceps and biceps brachii and muscles immediately before and after exercise.

Study Timeline

• Study Start: 2022-01-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-05-01
• Study First Submitted: 2023-02-24
• Status Verified: 2023-03
• Study First Submitted QC: 2023-03-10
• Last Update Submitted: 2023-03-10
• Study First Posted: 2023-03-23
• Last Update Posted: 2023-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Patients had undergone primary unilateral total knee replacement surgery
• Patients hospitalized for at least seven days were enrolled in this study.

Exclusion Criteria

• Medically stable patients who used glucocorticoids or strong analgesic drugs
• Patients had post-traumatic OA, rheumatoid arthritis (RA), psoriatic arthritis, cognitive, hearing and visual problems Patients were diagnosed chronic pain condition were excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HIE program	High Intensity Exercises Program	HIE program ; High Intensity Exercises Program. 3 sets of 15 repetition
HIE program	Low Intensity Exercises Program	HIE program ; High Intensity Exercises Program. 3 sets of 15 repetition
LIE Program	Low Intensity Exercises Program	Low Intensity Exercises program 2 sets of 8 repetition
LIE Program	High Intensity Exercises Program	Low Intensity Exercises program 2 sets of 8 repetition

Primary Outcome Measures

Name	Time	Method
Change of Pressure pain theshold	admission to hospital service to discharge from hospital service, an average 5 days	Pressure pain threshold (PPTs) were assessed using a handheld pressure algo-meter
change of pain severity	admission to hospital service to discharge from hospital service, an average 5 days	. The pain severity evaluated using a visual analogue scale (VAS; scored from 0, no pain, to 100, the worst pain ever).

Trial Locations

Locations (1)

Merve Karapinar; 🇹🇷 Isparta, Turkey