Exercise-Induced Hypoalgesia Differences Between Upper and Lower Limbs Resistance Training Interventions

Not Applicable

Recruiting

• Conditions: Local Hypoalgesia; Distal Hypoalgesia; Resistance Training; Pressure Pain Thresholds

• Registration Number: NCT06765486
• Lead Sponsor: Centro Universitario La Salle

Brief Summary

This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb resistance training intervention, another using an upper limb resistance training, and a control group. The exercise protocol involves 3 sets of 5 repetitions of resistance exercises (brachial biceps curl and leg extensions). Exercise-induced hypoalgesia will be assessed by measuring pressure pain thresholds in the thigh and elbow, comparing exercise interventions with the control group. Additionally, a secondary objective is to compare the lower limb and upper limb resistance training groups in terms of their effects on pressure pain thresholds in the thigh and elbow. Thus, the study anticipates observing differences in local and distal hypoalgesia based on the trained region.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-01-03
• Study First Submitted QC: 2025-01-03
• Study First Posted: 2025-01-09
• Status Verified: 2025-02
• Study Start: 2025-02-15
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-26
• Primary Completion: 2025-05-20
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Asymptomatic subjects aged between 18 and 64 years.

Exclusion Criteria

• Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.
• History of epilepsy.
• Pregnant.
• Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pain pressure threshold (PPT) on dominant quadriceps and dominant brachial biceps	before, immediately after intervention, and 30 minutes after intervention.	PPT is tested on the muscle belly of the quadriceps on the dominant side, at half of the distance between the anterior-superior iliac spine and the superior pole of the patella, and on the muscle belly of the brachial biceps on the dominant side, at a point one-fourth of the distance from the elbow crease to the lateral border of the acromion. The region to be pressed is marked with a pen. The patient is instructed to report the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The instrument measures 0 to 25 kg, with a higher score interpreted as a hypoalgesia response. The measurement is started on the quadriceps and alternated with the biceps until 3 measurements of each region are obtained. Each measurement in the same region is obtained after 30 seconds of rest. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).

Secondary Outcome Measures

Name	Time	Method
International Physical Activity Questionnaire (IPAQ)	before intervention (up 5 minutes)	7-item questionnaire on the level of physical activity at different intensities (high, moderate, and low) and hours sitting.; A higher score means higher weekly physical activity
Physical Activity Readiness Questionnaire (PAR-Q)	before intervention (up 5 minutes)	7-item questionnaire that assesses an individual's readiness to engage in physical activity based on whether any known contraindications have been ruled out by the participant.; If all the questions are negative, the participant can safely engage in a physical activity.
Fatigue Assessment Scale (FAS)	before intervention (up 5 minutes)	10-item questionnaire that allows for the evaluation of the participant's current level of fatigue. This instrument measures 10 to 50 points.; A higher score means higher fatigue.
Rate of perceived exertion (RPE)	immediately after intervention (up 10 seconds)	RPE Borg CR-10 is used to measure how hard your body works during physical activity. It runs from 0 - 10, using numbers to rate how much effort an activity takes. Higher scores indicate a higher perception of effort.

Trial Locations

Locations (1)

CSEU LaSalle; 🇪🇸 Madrid, Spain