The Effects of Intensity on Exercise-Induced Hypoalgesia During a Knee Extension Exercise

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Seated knee extension exercise

• Registration Number: NCT05561582
• Lead Sponsor: University of Central Florida

Brief Summary

The primary purpose of this study is to to compare immediate changes in pressure pain threshold at the exercising muscle (quadriceps) and a non-exercising muscle (upper trapezius) during low and high weight knee extension exercise. Participants will attend one session that consists of pain sensitivity testing, completion of pain-related psychological questionnaires, and random assignment to one of three interventions: 1) knee extension exercise with a high weight, 2) knee extension exercise with a low weight, or 3) quiet rest.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-09-27
• Study First Submitted QC: 2022-09-27
• Study First Posted: 2022-09-30
• Study Start: 2022-10-31
• Primary Completion: 2023-03-27
• Study Completion: 2023-03-27
• Results First Submitted: 2024-05-31
• Status Verified: 2024-10
• Results First Submitted QC: 2024-10-30
• Last Update Submitted: 2024-10-30
• Results First Posted: 2024-12-09
• Last Update Posted: 2024-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Pain-free
• 18-60 years old
• Participant can appropriately perform the knee extension exercise (assessed during screening)

Exclusion Criteria

• Non-English speaking
• Regular use of prescription pain medications
• Current or history of chronic pain condition
• Currently taking blood-thinning medication
• Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
• Any contraindication to the application of ice, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
• Known presence of cardiovascular, pulmonary, or metabolic disease
• Current use of tobacco products
• Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
• Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High Intensity Exercise	Seated knee extension exercise	Participants will complete a knee extension exercise with weight equivalent to 75% of their 1-repetition maximum for 3 sets of 10 repetitions.
Low Intensity Exercise	Seated knee extension exercise	Participants will complete a knee extension exercise with weight equivalent to 30% of their 1-repetition maximum for 3 sets of 10 repetitions.

Primary Outcome Measures

Name	Time	Method
Pressure Pain Threshold	1 day	A digital pressure algometer will be applied to the quadriceps and upper trapezius for two trials each. Participants are instructed to say "stop" or "pain" so the stimulus can be terminated "when the sensation first transitions from pressure to pain" (pain threshold). Participants will rate the pain experienced during the threshold testing using a 101-point numeric pain rate scale (NPRS) anchored with 0= no pain to 100= the most intense pain sensation imaginable immediately following each testing time.

Secondary Outcome Measures

Name	Time	Method
Conditioned Pain Modulation	1 day	Pressure pain threshold after an cold water immersion task will be measured.

Trial Locations

Locations (1)

University of Central Florida; 🇺🇸 Orlando, Florida, United States