Adjunctive antimicrobial therapy of Periodontitis: long-term effects on disease progression and oral microbiological colonisation

niversity Hospital Muenster (Germany)0 sites500 target enrollmentMarch 30, 2007

Overview

Registry

who.int

Start Date

March 30, 2007

End Date

January 1, 2012

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity Hospital Muenster (Germany)

•Current inclusion criteria as of 01/08/2008:
•Subjects selected for the study must meet the following inclusion criteria:
•1\. Periodontal Screening Index (PSI) of IV in at least one sextant
•2\. Range from 18 to 75 years of age with clinical and radiographic signs of moderate (Clinical Attachment Loss \[CAL] of 3 to 4 mm) to severe (CAL 5 mm or more) chronic or aggressive periodontitis
•3\. At least 10 natural teeth in situ
•4\. Pocket Probing Depths (PPDs) of greater than or equal to 6 mm at a minimum of four teeth
•5\. Willingness to participate and to be available at all times required for participation
•6\. Willingness to abstain from using antimicrobial mouth\-rinses during the study except for those explicitly prescribed
•7\. The informed consent signed by the patient
•8\. Sufficient knowledge of German language

•Current exclusion criteria as of 01/08/2008:
•1\. Report themselves confirmed or assumed allergies or hyper\-sensitive skin reactions against amoxicillin, metronidazol or lactose, or in parents or siblings
•2\. Have Downs syndrome
•3\. Known acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV)
•4\. Regularly take drugs that may affect the periodontal conditions, e.g. phenytoine, nifedipine, and/or steroid drugs
•5\. Professional periodontal therapy during the six months preceding the baseline clinical evaluation
•6\. Require antibiotic treatment for dental appointments
•7\. Are undergoing or require extensive dental or orthodontic treatment
•8\. Are pregnant or breastfeeding
•9\. Have rampant caries