Intraocular Pressure in Corticosteroid-treated Dermatology Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Change in intraocular pressure from baseline
研究概览
简要总结
Ocular hypertension and glaucoma are eye conditions associated with abnormally high fluid pressure in the eye (called intraocular pressure or IOP). If left untreated, the elevated IOP may eventually cause damage to the nerve of the eye and potential impairment of vision.
The use of certain drugs has been identified as a risk factor for raised IOP, including various forms of administration of corticosteroids. Corticosteroids can also lead to cataract, which is clouding of the lens in the eye that can affect vision.
In this research study, we would like to find out whether the use of corticosteroids in our dermatology clinic leads to raised IOP, in order to identify patients at risk and to allow them to be more closely monitored than others. It is important to identify those patients who have a corticosteroid-induced pressure rise early enough to prevent them from permanent glaucomatous visual loss.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients on whom corticosteroid treatment is being introduced for a duration of at least 12 weeks
排除标准
- •pregnant women
- •patients already under glaucoma treatment
- •patients unable to give informed written consent or those unable to cooperate fully with the assessments
研究组 & 干预措施
Potent topical steroid-treated
Patients treated with potent topical steroids
干预措施: Potent topical steroid (Drug)
Superpotent topical steroid-treated
Patients treated with superpotent topical steroids
干预措施: Superpotent topical steroid (Drug)
结局指标
主要结局
Change in intraocular pressure from baseline
时间窗: after 1, 2 and 3 months
Measurements will be done at 28 (+/- 7 days) days, 56 (+/- 7 days) days, and 90 (+/- 7 days)days after initiation of topical steroids.
次要结局
- Whether there is any clinical evidence of cataract at the final visit of the study.(After 1, 2 and 3 months)
研究者
Yasaman Mansouri, MD
Specialist Registrar in Dermatology
University Hospitals Coventry and Warwickshire NHS Trust
