Therapeutic Effect of Dietary Omega-6 and Omega-3 Fatty Acids in Improving Social Impairment in Youth With Autism Spectrum Disorders: A Double-Blind, Randomized, Placebo-Controlled Trial
- Conditions
- Autism Spectrum Disorders including autism and Asperger disorder
- Registration Number
- JPRN-jRCT1091220041
- Lead Sponsor
- Kunio Yui
- Brief Summary
The present preliminary study suggests the possibility that supplementation with larger ARA doses added to DHA improves social impairment in individuals with ASD by upregulating signal transduction or reducing oxidative stress.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
13 individuals who met DSM-IV-R criteria for high functioning autistic disorder or Asperger's Disorder, corroborated by the Autism Diagnostic Interview-Revised. Participants were free of any medical or comorbid psychiatric disorders. Other inclusion criteria included either a verbal or performance intelligence quotient above 80, and a score greater than 10 on the social withdrawal subscale of the Aberrant Behavior Checklist-Community (ABC)
Subjects who have total intelligence quotient is 79 or under score, lower than 10 of ABC-C social withdrawal subscale score, and medical treatment or taking other drugs due to other psychiatric disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Abberant Behavior Cheklist-community (ABC-C),Social Responsiveness Scale (SRS)
- Secondary Outcome Measures
Name Time Method Social Interaction and repetitive, stereotyped pattern of behavior and interest subscales of Autism Diagnostic Interview-revised (ADI-R)