Effects of Neuromuscular Electrical Stimulation on Functional Exercise Capacity and Quality of Life in Patients With Interstitial Lung Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Gazi University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Functional exercise capacity
Study Overview
Brief Summary
Decreased exercise capacity and quality of life, increased dyspnea and fatigue perception and hypoxemia during exercise is seen in patients with interstitial lung disease. Impaired ventilatory response, increased lung compliance, ventilation-perfusion mismatching and inadequate peripheral circulation causes decreased exercise capacity. Another important factor that induce decreased exercise capacity is peripheral muscle weakness. In literature, there is no study investigated effects of neuromuscular electrical stimulation on functional exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, physical activity level, dyspnea and fatigue perception in patients with interstitial lung disease.
Detailed Description
In literature, there was increased quantity of study investigated effects of neuromuscular electrical stimulation in chronic lung disease patients. It was used as a pulmonary rehabilitation component especially in patients with decreased exercise capacity and peripheral muscle strength, intensely increased dyspnea inhibits exercise. It was demonstrated that neuromuscular electrical stimulation improved functional exercise capacity, peripheral muscle strength and quality of life.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosed with interstitial lung disease
- •Clinically stable
- •Under standard medication
- •Having no exacerbation or infection
Exclusion Criteria
- •Cognitive disorders
- •Orthopedic and neurological problems
- •Contraindications to apply the neuromuscular electrical stimulation (pace maker, sensory defects, etc...)
Arms & Interventions
NMES Group
Intervention: NMES group will receive neuromuscular electrical stimulation using high frequency galvanic stimulation and breathing exercises.
Neuromuscular electrical stimulation will be applied bilaterally to quadriceps femoris muscle for 3days/6 weeks by a physiotherapist.
NMES group will also perform breathing exercises 120 times/day, 7 days/week, for 6 weeks.
Intervention: NMES Group (Other)
Control Group
Sham: Control group will receive breathing exercises. Control group will perform breathing exercises 120 times/day, 7 days/week, for 6 weeks.
Control group will be followed-up by telephone once a week.
Intervention: Control Group (Other)
Outcomes
Primary Outcomes
Functional exercise capacity
Time Frame: 6 weeks
Six minute walk test
Secondary Outcomes
- Depression(6 weeks)
- Generic quality of life(6 weeks)
- Disease specific quality of life(6 weeks)
- Pulmonary functions(6 weeks)
- Inspiratory and expiratory muscle strength (MIP,MEP)(6 weeks)
- Dyspnea(6 weeks)
- Peripheral muscle strength(6 weeks)
- Fatigue(6 weeks)
- Physical activity(6 weeks)
- Cough related quality of life(6 weeks)
- Maximal exercise capacity(6 weeks)
Investigators
Meral Boşnak Güçlü
Assoc. Prof
Gazi University