Mechanisms of Exacerbation of Asthma
概览
- 阶段
- 不适用
- 干预措施
- Asthma
- 疾病 / 适应症
- Asthma
- 发起方
- University of California, San Francisco
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma
- 状态
- 终止
- 最后更新
- 上个月
概览
简要总结
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.
详细描述
In this study, we will explore mechanisms of exacerbation in asthma by careful characterization studies in asthmatics presenting in acute severe exacerbation. Specifically, we will determine the frequency of secretor status in these subjects by blood and saliva testing, and we will also perform a detailed cellular and biochemical analysis of their airway secretions. We will collect airway secretions using two methods. One method will be to have subjects cough sputum into a clean plastic container. The other method only applies to asthmatics with near-fatal asthma requiring intubation and mechanical ventilation. In these asthmatics, we will collect airway secretions by tracheal aspirate using methods normally applied in their clinical care.
研究者
入排标准
入选标准
- •Male and female subjects with a history of asthma between the ages of 18 to 75 years.
- •Physician diagnosis of asthma.
- •Currently experiencing an acute exacerbation of asthma. This exacerbation may be severe necessitating treatment in the emergency room, ICU, or hospital ward.
- •Ability to provide informed consent.
排除标准
- •Lung disease other than asthma.
- •Females who are lactating or who are pregnant.
- •Use of recreational drugs in the 1 month preceding the study.
研究组 & 干预措施
Asthma
People who have been diagnosed with Asthma
结局指标
主要结局
rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma
时间窗: 1-2 years