Efficacy of Mirabegron versus Tamsulosin monotherapy in patients with Benign Prostatic Hyperplasia(BPH) with coexisting Overactive Bladder Symptoms-A Randomised Clinical Study.

niversity College of Medical Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1.Male patients aged 40-80 years diagnosed as symptomatic BPH with coexisting overactive bladder symptoms (OABS) with an IPSS >8 and not desiring surgery.
•2.Symptomatic patients of BPH (determined by LUTS and supplemented by IPSS/focused urological exam/Investigations) associated with any one or more of the following overactive bladder symptoms like; micturition frequency of >8 per 24 hrs, nocturia episodes of > 2 per 24 hrs, urgency episodes of >1 per 24 hrs with or without urge incontinence.
•3.Patients should be willing and able to complete a 3 day voiding diary and questionnaires.

•1.Patient not willing for consent for inclusion in the above study and those who cannot comply with the study protocol due to concomitant CVA, CRF, Vesical stones, untreated UTI Diabetic neuropathy ,uncontrolled hypertension (BP >180/100), neurological ds etc.
•2.Patients of BPH with absolute indications for surgery
•3.Patients with contraindication, hypersensitivity and allergic reaction to components of mirabegron and or tamsulosin hydrochloride.
•4.Patients on drugs known to interfere with pharmacodynamics of tamsulosin/mirabegron.
•5.Patients with prior history of prostatic/urethral surgery, acute or chronic prostatitis, known prostate cancer, suspected neurogenic bladder, urethral stricture and priapism.

发起方

niversity College of Medical Sciences