Long Term Prospective Study of Tai Chi Intervention to Prevent MCI From Conversion to Dementia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Ruijin Hospital
- Enrollment
- 206
- Primary Endpoint
- Incidence of MCI converted to Alzheimer's disease.
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This study evaluates the effects of 3 years-Tai Chi exercise intervention on cognitive function in MCI patients and to clarify whether the intervention can prevent MCI from conversion to dementia. Patients will be randomized into the Tai chi training group and the control group.
Detailed Description
Dementia is a syndrome of impairments of cortical functions caused by brain diseases. More than 55 million people worldwide are currently living with dementia, with nearly 10 million new cases each year. Alzheimer's disease is the most common form of dementia and may account for 60-70% of patients with dementia. Mild cognitive impairment (MCI) is an intermediate state between normal cognitive aging and dementia. About 10% to 15% of patients with MCI progress to dementia each year. Therefore, it is crucial to find intervention strategies to prevent the progression of MCI to dementia. However, drug interventions are currently ineffective in the prevention of dementia. Based on the synaptic plasticity, more and more studies focus on non-drug interventions. Our research group previously found 6-months non-drug interventions (cognitive training, exercise therapy) can effectively delay cognitive decline in the elderly, providing a new strategy for the improvement of cognition in the elderly. Therefore, this project plans to conduct a multi-site, randomized, parallel-controlled clinical trial to examine the effect of 3 years-Tai Chi exercise intervention on cognitive function in MCI patients and to clarify whether the intervention can prevent MCI from conversion to dementia.
Investigators
Shengdi Chen
Professor
Ruijin Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Incidence of MCI converted to Alzheimer's disease.
Time Frame: 36 months
The 3-year incidence of AD in each group will be compared.
The global cognitive function of MCI patients.
Time Frame: 18 months and 36 months
11-item Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog 11) will be used to assess the global cognitive performance of MCI patients. The total score of ADAS-cog/11 is 0-70, with higher scores mean a worse outcome.
Secondary Outcomes
- Memory(18 months and 36 months)
- Attention(18 months and 36 months)
- Executive function(18 months and 36 months)
- Language(18 months and 36 months)
- Working memory test(18 months and 36 months)
- Visual spatial ability(18 months and 36 months)
- Change from baseline in MMSE score(18 months and 36 months)
- Change from baseline in MoCA score(18 months and 36 months)
- Change from baseline in CDR score(18 months and 36 months)
- Activities of daily living(18 months and 36 months)
- Anxiety(18 months and 36 months)
- Depression(18 months and 36 months)
- Sleep(18 months and 36 months)
- Brain activity(36 months)
- Neurodegeneration in brain structures(36 months)
- Gut microbiota(18 months and 36 months)
- Blood biomarkers(18 months and 36 months)