Dose-Response Effects of Tai Chi Chuan Interventions on Cognitive Function in Mild Cognitive Impairment

Lidian Chen0 sites540 target enrollmentMay 1, 2024

ConditionsMild Cognitive Impairment

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Mild Cognitive Impairment
Sponsor: Lidian Chen
Enrollment: 540
Primary Endpoint: Montreal Cognitive Assessment
Status: Not yet recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.

Detailed Description

Taking MCI as a potential gateway, early intervention to delay the occurrence of dementia has become an important consensus in this field. Exercise is an important means to improve cognitive function in MCI, but the effect of exercise is influenced by the dosage. Tai Chi Chuan, is a moderate intensity aerobic exercise. Previous studies by our team and others had confirmed its effect on cognitive function in MCI. However, the dose parameters of Tai Chi Chuan exercise varied in these studies, and the dose-response relationship is still unclear. The purpose of this study is to explore the dose-response relationship between different volume of Tai Chi Chuan exercise and cognitive function（global cognition and cognition of subdomains）in elderly MCI patients.

Registry

clinicaltrials.gov

Start Date

May 1, 2024

End Date

September 30, 2025

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Lidian Chen

Responsible Party

Sponsor Investigator

Principal Investigator

Lidian Chen

PhD

Fujian University of Traditional Chinese Medicine

Eligibility Criteria

Inclusion Criteria

•Presence of mild cognitive impairment, not demented;
•Age ≥ 60 years old;
•Informed consent and voluntary participation.

Exclusion Criteria

•Geriatric Depression Scale score ≥ 9 points
•Cognitive impairment caused by other reasons, taking drugs, poisoning, etc;
•Suffer from severe musculoskeletal system diseases and other contraindications to exercise and are not suitable for Tai Chi training, such as those who suffer from stroke, Parkinson's disease, and have a history of lower limb arthritis, hip and knee joint replacement, etc;
•Patients with severe heart, liver, kidney failure, malignant tumors, and other major diseases;
•Individuals with visual/auditory impairments, writing/reading impairments, illiteracy, etc. that affect training and evaluation;
•Individuals with uncontrolled hypertension (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg after medication);
•Participating in other experiments that influence this study;
•Engaged in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time.

Outcomes

Primary Outcomes

Montreal Cognitive Assessment

Time Frame: 8 weeks, 16 weeks, 24 weeks

Global cognition

Secondary Outcomes

Montreal Cognitive Assessment(52 weeks)
Wechsler Memory Scale(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Trial Making Test part B(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Rey-Osterrieth complex graphics test(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Rey Auditory Verbal Learning Test(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Digital Symbol test(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Stroop color word test(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)
Boston naming test(8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks)