Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)
- Conditions
- Percutaneous Coronary InterventionAtrial Fibrillation
- Interventions
- Registration Number
- NCT02164864
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
The main objective of this study is to compare a Dual Antithrombotic Therapy (DAT) regimen of 110mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (110mg dabigatran etexilate (DE) DAT) and 150mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (150mg DE-DAT) with a Triple Antithrombotic Therapy (TAT) combination of warfarin plus clopidogrel or ticagrelor plus Aspirin (ASA) \<= 100mg once daily (warfarin-TAT) in patients with Atrial Fibrillation that undergo a PCI with stenting (elective or due to an Acute Coronary Syndrome).
The study aims to show non-inferiority of each dose of DE-DAT when compared to Warfarin-TAT in terms of safety. Safety will be determined by comparing the rates of bleeding events, assessed using the modified International Society of Thrombosis and Haemostasis classification of Major Bleeding and Clinically Relevant Non Major Bleeding Events.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2725
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Warfarin Warfarin 5mg Warfarin doses to maintain INR Dabigatran Etexilate 110mg Clopidogrel or Ticagrelor Patient to receive Dabigatran Etexilate 110mg twice a day (BID) Dabigatran Etexilate 150mg Clopidogrel or Ticagrelor Patient to receive Dabigatran Etexilate 150mg twice a day (BID) Warfarin Warfarin 1mg Warfarin doses to maintain INR Warfarin Warfarin 3mg Warfarin doses to maintain INR Dabigatran Etexilate 110mg Dabigatran Etexilate 110mg Patient to receive Dabigatran Etexilate 110mg twice a day (BID) Warfarin Clopidogrel or Ticagrelor Warfarin doses to maintain INR Dabigatran Etexilate 150mg Dabigatran Etexilate 150mg Patient to receive Dabigatran Etexilate 150mg twice a day (BID) Warfarin Aspirin Warfarin doses to maintain INR
- Primary Outcome Measures
Name Time Method Time to First Adjudicated ISTH MBE or CRNMBE up to 30 months Time to event analysis of patients with first adjudicated International Society of Thrombosis and Haemostasis (ISTH) Major Bleeding Event (MBE) or Clinically Relevant Non Major Bleeding Event (CRNMBE). The number of observed patients with adjudicated ISTH MBE or CRNMBE was reported.
Full analysis set (FAS): All consenting patients randomised were analysed in the treatment group to which they were randomised regardless of whether they took trial medication. The start date of the observation period for this analysis set was the date of randomisation. Patients who discontinued trial medication were followed until the end of the trial.
Patients who were lost to follow-up for vital status were censored for the primary endpoint at the time of their last known vital status.
Intention to treat period: The observation period for these analysis was the so called 'intention to treat period'.
- Secondary Outcome Measures
Name Time Method Time to First Adjudicated Stroke up to 30 months Time to event analysis of patients with first adjudicated Stroke. The number of observed patients with adjudicated Stroke was reported.
Stroke was defined as an acute episode of focal or global neurological dysfunction caused by brain, spinal cord, or retinal vascular injury as a result of haemorrhage or infarctionTime to First Adjudicated Unplanned Revascularisation by PCI/CABG up to 30 months Time to event analysis of patients with adjudicated unplanned revascularisation by Percutaneous Coronary Intervention (PCI)/Coronary Artery Bypass Graft (CABG). The number of observed patients with adjudicated unplanned revascularisation by PCI/CABG was reported.
Time to Death or First Thrombotic Event or Unplanned Revascularisation by PCI/CABG up to 30 months Time to event analysis of patients with death or thrombotic event (all death, myocardial infarction, stroke/systemic embolism) or unplanned revascularisation by Percutaneous Coronary Intervention/Coronary Artery Bypass Graft. The number of observed patients with death or first thrombotic event or unplanned revascularisation by PCI/CABG was reported.
Time to Adjudicated Non-CV up to 30 months Time to event analysis of patients with adjudicated Non-cardiovascular (Non-CV). The number of observed patients with adjudicated Non-CV was reported.
Non-CV death was defined as any death with a specific cause that was not thought to be CV. These were possible examples of non-CV causes of death: Pulmonary, Renal, Gastrointestinal, Hepatobiliary, Pancreatic Infection(included sepsis), Inflammatory (e.g. systemic inflammatory response syndrome) or immune (including autoimmune), Haemorrhage that was neither CV bleeding nor a stroke, Non-CV procedure or surgery, Trauma, Suicide, Non-prescription drug reaction or overdose, Prescription drug reaction or overdose, Neurological (non-CV), Malignancy, Other non-CVTime to First Adjudicated MI up to 30 months Time to event analysis of patients with first adjudicated Myocardial Infarction (MI). The number of observed patients with adjudicated MI was reported
Time to Composite Endpoint of Death + MI + Stroke up to 30 months Time to event analysis of patients with the composite endpoint of death + myocardial infarction (MI) + stroke. The number of observed patients with the composite endpoint of death + myocardial infarction (MI) + stroke was reported.
Time to Composite Endpoint of Death or First Thrombotic Event up to 30 months Time to event analysis of patients with composite endpoint of death or first thrombotic event (all death, myocardial infarction (MI), stroke/systemic embolism (SE)). The number of observed patients with composite endpoint of death or thrombotic event (all death, MI, stroke/SE).
Time to Adjudicated All Cause Death up to 30 months Time to event analysis of patients with adjudicated all cause death. The number of observed patients with adjudicated all cause death was reported. All cause death is defined as the death from any cause included CV death, non-CV death, and undetermined cause of death.
Time to First Adjudicated SE up to 30 months Time to event analysis of patients with first adjudicated Systemic embolism (SE). The number of observed patients with adjudicated SE was reported.
SE is an acute vascular occlusion of the extremities or any organ (kidneys, mesenteric arteries, spleen, retina or grafts) and had to be documented by angiography, surgery, scintigraphy, or autopsy.Time to Adjudicated Undetermined Cause of Death up to 30 months Time to event analysis of patients with adjudicated Undetermined cause of death. The number of observed patients with adjudicated Undetermined cause of death was reported.
This is referred to a death not attributable to cardiovascular (CV) death or to a non-cardiovascular (non-CV) cause. Inability to classify the cause of death may have been due to lack of information (e.g. the only available information was "patient died") or when there was insufficient supporting information or detail to assign the cause of death.Time to Adjudicated CV up to 30 months Time to event analysis of patients with adjudicated Cardiovascular (CV) death. The number of observed patients with adjudicated Cardiovascular (CV) death was reported.
CV death included death resulting from an acute myocardial infarction, sudden cardiac death, death due to heart failure, death due to stroke, death due to CV procedures, death due to CV haemorrhage, and death due to other CV causes.Time to First Adjudicated ST up to 30 months Time to event analysis of patients with first adjudicated Stent Thrombosis (ST). The number of observed patients with adjudicated ST was reported.
Trial Locations
- Locations (418)
CLI du Pont de Chaume
🇫🇷Montauban, France
Hospital Jihlava
🇨🇿Jihlava, Czechia
Klinikum Coburg gGmbH
🇩🇪Coburg, Germany
University General Hospital of Heraklion
🇬🇷Heraklion, Crete, Greece
Bursa Yuksek Ihtisas EAH
🇹🇷Bursa, Turkey
Mid Michigan Medical Center
🇺🇸Midland, Michigan, United States
Inst.Cardiovascular San Luis
🇦🇷San Luis, Argentina
Covenant Medical Center, Inc.
🇺🇸Saginaw, Michigan, United States
Wichita Falls Heart Clinic
🇺🇸Wichita Falls, Texas, United States
Holy Family Memorial, Inc
🇺🇸Manitowoc, Wisconsin, United States
Chambersburg Hospital
🇺🇸Chambersburg, Pennsylvania, United States
Wilhelminenspital
🇦🇹Wien, Austria
Instituto Cardiovascular de Buenos Aires
🇦🇷Caba, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
🇦🇷Capital Federal, Argentina
Saint Mary's Medical Center dba Essentia Health Saint Mary's Medical Center
🇺🇸Duluth, Minnesota, United States
Kansas City Veterans Administration Medical Center
🇺🇸Kansas City, Missouri, United States
Pinnacle Health Harrisburg Hospital
🇺🇸Harrisburg, Pennsylvania, United States
Cape Cod Research Institute
🇺🇸Hyannis, Massachusetts, United States
Cardiovascular Research Center
🇺🇸Toledo, Ohio, United States
Hospital Sao Paulo - UNIFESP
🇧🇷Sao Paulo, Brazil
Fundación Favaloro
🇦🇷Caba, Argentina
VA Western New York Healthcare System
🇺🇸Buffalo, New York, United States
Sanatorio Allende
🇦🇷Córdoba, Argentina
LKH Salzburg, Univ. Clinic
🇦🇹Salzburg, Austria
Investigaciones Clinicas Tucumán
🇦🇷San Miguel de Tucumán, Argentina
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Chattanooga Heart Institute
🇺🇸Chattanooga, Tennessee, United States
Irmandade da Santa Casa de Misericordia de Curitiba
🇧🇷Campina Grande do Sul, Brazil
Hospital Italiano de Buenos Aires
🇦🇷Caba, Argentina
Order Hospital Elisabethinen Linz
🇦🇹Linz, Austria
Tienen - PRAC De Wolf, Axel
🇧🇪Tienen, Belgium
Kawartha Cardiology Clinical Trials
🇨🇦Peterborough, Ontario, Canada
Eurolatino pesquisas Médicas Ltda
🇧🇷Uberlandia, Brazil
Specialized Hosp.f.Active Treatment, Cardiology Dept, Yambol
🇧🇬Yambol, Bulgaria
Hamilton General Hospital
🇨🇦Hamilton, Ontario, Canada
General Faculty Hospital, Prague
🇨🇿Praha, Czechia
Karlovarska Reg.Hosp, Cardiology Dept, Karlovy Vary
🇨🇿Karlovy Vary, Czechia
CHUS Fleurimont
🇨🇦Sherbrooke, Quebec, Canada
Instituto de Cardiologia Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Aalst - HOSP Onze-Lieve-Vrouw
🇧🇪Aalst, Belgium
Brussels - UNIV UZ Brussel
🇧🇪Brussel, Belgium
Dr. R. Labonte Prof. Med. Corp
🇨🇦Sudbury, Ontario, Canada
Amkardia, s.r.o. Brno
🇨🇿Brno, Czechia
Instituto Dante Pazzanese de Cardiologia
🇧🇷Sao Paulo, Brazil
SHAT in Cardiology EAD, Pleven
🇧🇬Pleven, Bulgaria
Calgary Heart Centre
🇨🇦Calgary, Alberta, Canada
HOP St Joseph
🇫🇷Marseille, France
HOP Pasteur
🇫🇷Nice, France
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada
St. Josef- und St. Elisabeth-Hospital gGmbH
🇩🇪Bochum, Germany
Centro Médico Imbanaco de Cali S.A.
🇨🇴Cali, Colombia
University Hospital of Alexandroupolis
🇬🇷Alexandroupoli, Greece
HOP CHU de Grenoble
🇫🇷Grenoble, France
University Hospital Motol
🇨🇿Praha, Czechia
IUCPQ (Laval University)
🇨🇦Ste-Foy, Quebec, Canada
Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
🇩🇪Bad Oeynhausen, Germany
Universitätsmedizin Göttingen, Georg-August-Universität
🇩🇪Göttingen, Germany
Städtisches Klinikum Dresden
🇩🇪Dresden, Germany
University Hospital Olomouc
🇨🇿Olomouc, Czechia
Universitätsklinikum des Saarlandes
🇩🇪Homburg/Saar, Germany
Vivantes Netzwerk für Gesundheit GmbH
🇩🇪Berlin, Germany
HYKS, Kardiologian klinikka, Sydän- ja keuhkokeskus
🇫🇮Helsinki, Finland
CLI Saint-Hilaire
🇫🇷Rouen, France
HOP Rangueil
🇫🇷Toulouse, France
Allgemeines Krankenhaus, Celle
🇩🇪Celle, Germany
Hospitals of Pardubice Region, Internal Department, Svitavy
🇨🇿Svitavy, Czechia
University Hospital of Patras
🇬🇷Patras, Greece
HOP de la Cavale Blanche
🇫🇷Brest Cedex 2, France
Municipal Hospital Ostrava
🇨🇿Ostrava, Czechia
Sana-Klinikum Remscheid GmbH
🇩🇪Remscheid, Germany
HOP Arnaud de Villeneuve
🇫🇷Montpellier cedex 5, France
HOP Salpêtrière, Cardio, Paris
🇫🇷Paris cedex 13, France
SLK-Kliniken Heilbronn GmbH
🇩🇪Bad Friedrichshall, Germany
Institute for Clinical and Experimental Medicine
🇨🇿Praha 4, Czechia
Hospital Slany, Internal Department
🇨🇿Slany, Czechia
CIMS Studienzentrum Bamberg GmbH
🇩🇪Bamberg, Germany
Hosp.of Pardubice Reg,Orlickoustecka,Internal Dept, Ustinad
🇨🇿Usti nad Orlici, Czechia
Kerckhoff-Klinik, Bad Nauheim
🇩🇪Bad Nauheim, Germany
St. Johannes Hospital Dortmund
🇩🇪Dortmund, Germany
Agaplesion Markus Krankenhaus
🇩🇪Frankfurt, Germany
Gottsegen Gyorgy Hungarian Instit.of Cardiology,Budapest
🇭🇺Budapest, Hungary
University of Pecs, Invasive Cardiology
🇭🇺Pecs, Hungary
Fortis Escorts Heart Institute
🇮🇳New Delhi, India
Milit.Hosp.-State Health Cent.
🇭🇺Budapest, Hungary
University Debrecen Hospital
🇭🇺Debrecen, Hungary
Chiba University Hospital
🇯🇵Chiba, Chiba, Japan
A.O.U. Policlinico Vittorio Emanuele
🇮🇹Catania, Italy
The Catholic University of Korea, Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Kokura Memorial Hospital
🇯🇵Fukuoka, Kitakyushu, Japan
Azienda Ospedaliera Vito Fazzi
🇮🇹Lecce, Italy
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Pusan National Univ. Hosp
🇰🇷Pusan, Korea, Republic of
Osaka City Hospital Organization Osaka City General Hospital
🇯🇵Osaka, Osaka, Japan
Kyungpook National Univ. Hosp
🇰🇷Daegu, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
National Hospital Organization Saitama National Hospital
🇯🇵Saitama, Wako, Japan
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Reg.Hosp Kielce,Swietokrzyskie,1.Clinic of Cardiology,Kielce
🇵🇱Kielce, Poland
Diskapi Yildirim Beyazit EAH
🇹🇷Ankara, Turkey
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
CS Parc Taulí
🇪🇸Sabadell (Barcelona), Spain
Waikato Hospital
🇳🇿Hamilton, New Zealand
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Ramón y Cajal
🇪🇸Madrid, Spain
Hospital La Paz
🇪🇸Madrid, Spain
Hospital Clínico de Santiago
🇪🇸Santiago de Compostela, Spain
Sahlgrenska Universitetssjukhuset, Östra
🇸🇪Göteborg, Sweden
North-Western Fed.Med.Resear.Centr na V.I.Almazov,Cardio.dep
🇷🇺St.Petersburg, Russian Federation
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Cukurova Universitesi Tip Fakultesi Kardiyoloji AnabilimDali
🇹🇷Adana, Turkey
Royal Derby Hospital
🇬🇧Derby, United Kingdom
Hospital de Bellvitge
🇪🇸L'Hospitalet Llobregat (bcn), Spain
University Medical Center Ljubljana
🇸🇮Ljubljana, Slovenia
Wycombe General Hospital
🇬🇧High Wycombe, United Kingdom
Hospital Clínico San Carlos
🇪🇸Madrid, Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Spain
Hospital Virgen del Rocío
🇪🇸Sevilla, Spain
Glenfield Hospital
🇬🇧Leicester, United Kingdom
James Cook University Hospital
🇬🇧Middlesbrough, United Kingdom
St Bartholomew's Hospital
🇬🇧London, United Kingdom
Royal Bournemouth and Christchurch Hospital
🇬🇧Bournemouth, United Kingdom
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Birmingham City Hospital
🇬🇧Birmingham, United Kingdom
Altnagelvin Area Hospital
🇬🇧Londonderry, United Kingdom
Royal Stoke University Hospital
🇬🇧Stoke-on-Trent, United Kingdom
Dorset County Hospital
🇬🇧Dorchester, United Kingdom
Arkansas Cardiology, PA
🇺🇸Little Rock, Arkansas, United States
HonorHealth Research Institute
🇺🇸Scottsdale, Arizona, United States
Verde Valley Medical Center
🇺🇸Cottonwood, Arizona, United States
University of Florida College of Medicine
🇺🇸Jacksonville, Florida, United States
Mission Cardiovascular Research Institute
🇺🇸Fremont, California, United States
Aurora Denver Cardiology Associates, PC
🇺🇸Aurora, Colorado, United States
Community Clinical Research Center
🇺🇸Anderson, Indiana, United States
Watson Clinic, LLP
🇺🇸Lakeland, Florida, United States
Ball Memorial Hospital
🇺🇸Muncie, Indiana, United States
Cardiovascular Institute of the South
🇺🇸Houma, Louisiana, United States
Richmond Cardiology Associates Research, LLC
🇺🇸Richmond, Indiana, United States
Novant Health Heart and Vascular Institute
🇺🇸Charlotte, North Carolina, United States
St. Michaels Medical Center
🇺🇸Newark, New Jersey, United States
North Dallas Research Associates
🇺🇸McKinney, Texas, United States
Sentara Norfolk General Hospital
🇺🇸Norfolk, Virginia, United States
Instituto de Cardiología de Corrientes
🇦🇷Corrientes, Argentina
Pendlebury Research
🇦🇺Adamstown, New South Wales, Australia
Wollongong Hospital
🇦🇺Wollongong, New South Wales, Australia
Gosford Hospital
🇦🇺Gosford, New South Wales, Australia
Royal North Shore Hospital
🇦🇺St Leonards, New South Wales, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
Hospital Santa Isabel
🇧🇷Blumenau, Brazil
MHAT "Deva Maria", Dept. of Cardiology, Burgas
🇧🇬Burgas, Bulgaria
INCOR e Hospital das Clínicas da Universidade de São Paulo
🇧🇷Sao Paulo, Brazil
St. Boniface General Hospital
🇨🇦Winnipeg, Manitoba, Canada
Thunder Bay Regional Health Science Centre
🇨🇦Thunder Bay, Ontario, Canada
Hospital San Juan de Dios
🇨🇱Santiago, Chile
Fundación Cardiovascular de Colombia
🇨🇴Floridablanca, Colombia
Masaryk Hospital, Usti nad Labem
🇨🇿Usti nad Labem, Czechia
HOP Ambroise Paré
🇫🇷Boulogne-Billancourt, France
HOP Gabriel-Montpied
🇫🇷Clermont-Ferrand, France
Klinikum Bielefeld gGmbH
🇩🇪Bielefeld, Germany
Herz- und Gefäßzentrum (HGZ-Göttingen) am Krankenhaus Neu Bethlehem
🇩🇪Göttingen, Germany
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Germany
HPK-Heidelberger Praxisklinik
🇩🇪Heidelberg, Germany
Westküstenkliniken Brunsbüttel und Heide gGmbH
🇩🇪Heide, Germany
Robert-Bosch-Krankenhaus GmbH
🇩🇪Stuttgart, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Germany
Städtisches Klinikum München GmbH
🇩🇪München, Germany
Klinikum der Universität München - Campus Großhadern
🇩🇪München, Germany
Universitätsklinikum Münster
🇩🇪Münster, Germany
St. Vincenz-Krankenhaus GmbH
🇩🇪Paderborn, Germany
Universitätsmedizin Rostock
🇩🇪Rostock, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Germany
Universitätsklinikum Ulm
🇩🇪Ulm, Germany
Marien-Hospital-Wesel gGmbH
🇩🇪Wesel, Germany
Helios Universitätsklinikum Wuppertal
🇩🇪Wuppertal, Germany
Hippokration Hospital, Univ Clinic of Cardiology
🇬🇷Athens, Greece
General Hospital of Athens Konstantopoulio-Agia Olga
🇬🇷Athens, Greece
General Hospital of Athens "Alexandra"
🇬🇷Athens, Greece
General Hospital of Attica "Sismanoglio - Amalia Fleming"
🇬🇷Athens, Greece
General Hospital of Chios, Department of Cardiology
🇬🇷Chios, Greece
University Hospital of Thessaloniki AHEPA
🇬🇷Thessaloniki, Greece
Univ. Gen. Hosp. of Ioannina
🇬🇷Ioannina, Greece
Prince of Wales Hosp, Dept of Med & Therapeutics
🇭🇰Hong Kong, Hong Kong
Queen Elizabeth Hospital
🇭🇰Hong Kong, Hong Kong
Semmelweis University
🇭🇺Budapest, Hungary
Bacs-Kiskun Megyei Onkormanyzat Hospital
🇭🇺Kecskemet, Hungary
Univ. of Szeged, 2nd Dept. of Internal Med., Haematology
🇭🇺Szeged, Hungary
B and M Patel Cardiac Centre, Shree Krishna Hospital,
🇮🇳Karamsad, India
Shri Krishna Hrudayalaya and Critical Care
🇮🇳Nagpur, India
St James's Hospital
🇮🇪Dublin, Ireland
University Hospital Galway
🇮🇪Galway, Ireland
Beaumont Hospital
🇮🇪Dublin, Ireland
Rambam Medical Center
🇮🇱Haifa, Israel
Wolfson Medical Center
🇮🇱Holon, Israel
Shaare Zedek Medical Center, Jerusalem 91031
🇮🇱Jerusalem, Israel
West.Galilee Med.Cent.Naharia
🇮🇱Naharia, Israel
Rabin Medical Center Beilinson
🇮🇱Petah Tikva, Israel
Ospedale San Donato di Arezzo
🇮🇹Arezzo, Italy
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
🇮🇹Bergamo, Italy
Fond. Poliambulanza Istituto
🇮🇹Brescia, Italy
Osp. Clin. SS. Anunziata
🇮🇹Chieti, Italy
Ospedale "Fabrizio Spaziani"
🇮🇹Frosinone, Italy
Ospedale della Misericordia
🇮🇹Grosseto, Italy
Osp. Pediatrico Aprano Pasquinucci
🇮🇹Massa, Italy
Ospedale Cardarelli
🇮🇹Napoli, Italy
Pol. Universitario Tor Vergata
🇮🇹Roma, Italy
Policlinico Gemelli
🇮🇹Roma, Italy
Presidio Ospedaliero di Saronno
🇮🇹Saronno (VA), Italy
Ospedale Bolognini
🇮🇹Seriate, Italy
Kobe University Hospital
🇯🇵Hyogo, Kobe, Japan
Shonan Fujisawa Tokushukai Hospital
🇯🇵Kanagawa, Fujisawa, Japan
Yokohama City Minato Red Cross Hospital
🇯🇵Kanagawa, Yokohama, Japan
Tokushima Red Cross Hospital
🇯🇵Tokushima, Komatsushima, Japan
Nishiarai Heart Center Hospital
🇯🇵Tokyo, Adachi-ku, Japan
Teikyo University Hospital
🇯🇵Tokyo, Itabashi-Ku, Japan
Nihon University Itabashi Hospital
🇯🇵Tokyo, Itabashi-Ku, Japan
Itabashi Chuo Medical Center
🇯🇵Tokyo, Itabashi-Ku, Japan
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
H. Central Dr Ignacio M. P.
🇲🇽San Luis Potosi, Mexico
Ziekenhuis Bernhoven Uden
🇳🇱Uden, Netherlands
CHLC, EPE - Hospital de Santa Marta
🇵🇹Lisboa, Portugal
Cntr of CV Surgery na Bakulev,Surg.Treatm of Inter.Path.dept
🇷🇺Moscow, Russian Federation
Kardiocentrum Nitra,Internal Medicine Dept, Nitra
🇸🇰Nitra, Slovakia
Hospital de Manises
🇪🇸Manises, Spain
Hospital Miguel Servet
🇪🇸Zaragoza, Spain
Länssjukhuset, Gävle
🇸🇪Gävle, Sweden
Universitetssjukhuset, Linköping
🇸🇪Linköping, Sweden
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
NCKUH
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Siyami Ersek Gogus Kalp ve Damar Cerrahisi Hastanesi
🇹🇷Istanbul, Turkey
Grantham District Hospital
🇬🇧Grantham, United Kingdom
Cardiovascular Associates of Mesa
🇺🇸Mesa, Arizona, United States
Midwest Cardiovascular Research and Education Foundation
🇺🇸Elkhart, Indiana, United States
Maine Medical Center
🇺🇸Portland, Maine, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
CentraCare Heart and Vascular Center
🇺🇸Saint Cloud, Minnesota, United States
Lourdes Cardiology Services
🇺🇸Voorhees, New Jersey, United States
Altru Health System
🇺🇸Grand Forks, North Dakota, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Dallas VA Medical Center
🇺🇸Dallas, Texas, United States
Scott and White Healthcare
🇺🇸Round Rock, Texas, United States
South Texas Cardiovascular Consultants
🇺🇸San Antonio, Texas, United States
University of Utah Health Sciences Center
🇺🇸Salt Lake City, Utah, United States
Bayview Physicians Services PC dba Cardiovascular Associates
🇺🇸Virginia Beach, Virginia, United States
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
Aarhus Universitetshospital
🇩🇰Århus N, Denmark
Cardiology P.C.
🇺🇸Birmingham, Alabama, United States
Länssjukhuset, Halmstad
🇸🇪Halmstad, Sweden
Lasarettet, Helsingborg
🇸🇪Helsingborg, Sweden
Skånes universitetssjukhus, Lund
🇸🇪Lund, Sweden
Skånes universitetssjukhus, Malmö
🇸🇪Malmö, Sweden
Danderyds Sjukhus
🇸🇪Stockholm, Sweden
Türkiye Yüksek Ihtisas Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Istanbul Universitesi Kardiyoloji Enstitusu
🇹🇷Istanbul, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
Bagcilar Egitim ve Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Medipol Mega Üniversitesi Hastanesi
🇹🇷Istanbul, Turkey
Istanbul Mehmet Akif Ersoy Egitim ve Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Kartal Kosuyolu Yuksek Ihtisas EAH
🇹🇷Istanbul, Turkey
Dokuz Eylul Unv. Tip Fakultesi
🇹🇷Izmir, Turkey
Izmir Katip Celebi Univ. EAH
🇹🇷Izmir, Turkey
Erciyes Universitesi Tip Fakultesi Kardiyoloji Anabilim Dali
🇹🇷Kayseri, Turkey
Ondokuz Mayis Universitesi Tip Fakultesi
🇹🇷Samsun, Turkey
Ospedale Molinette, AO Città della Salute e della
🇮🇹Torino, Italy
Lincoln County Hospital
🇬🇧Lincoln, United Kingdom
Hospital de Base - Fac Med de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, Brazil
Helios Amper-Klinikum Dachau
🇩🇪Dachau, Germany
Universitätsklinikum Bonn AöR
🇩🇪Bonn, Germany
Praxisklinik Herz und Gefäße
🇩🇪Dresden, Germany
Städtisches Klinikum, Fulda
🇩🇪Fulda, Germany
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Evangelisches Krankenhaus Düsseldorf
🇩🇪Düsseldorf, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
🇩🇪Langen, Germany
Cardiologicum Hamburg
🇩🇪Hamburg, Germany
Universitätsklinikum Jena
🇩🇪Jena, Germany
Klinikum der Stadt Ludwigshafen am Rhein gGmbH
🇩🇪Ludwigshafen, Germany
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
🇩🇪Lüdenscheid, Germany
Universitätsklinikum Magdeburg AöR
🇩🇪Magdeburg, Germany
Herzzentrum Leipzig GmbH
🇩🇪Leipzig, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
🇩🇪Mainz, Germany
Carl-von-Basedow Klinikum Saalekreis gGmgH
🇩🇪Merseburg, Germany
Universitätsklinikum Mannheim GmbH
🇩🇪Mannheim, Germany
Saint Anthony's Medical Center
🇺🇸Saint Louis, Missouri, United States
Hospital de Galdakao
🇪🇸Vizcaya, Spain
Yeungnam University Medical Center
🇰🇷Daegu, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
St.Carollo Hospital
🇰🇷Suncheon, Korea, Republic of
Wonju Severance Christian Hosp
🇰🇷Wonju, Korea, Republic of
Byramjee Jeejeebhoy Medical College
🇮🇳Pune, India
State Instit.Kazan Fed.Univ.
🇷🇺Kazan, Russian Federation
Instituto CER
🇦🇷Quilmes, Argentina
The Jackson Clinic, PA
🇺🇸Jackson, Tennessee, United States
Gumma Prefectural Cardiovascular Center
🇯🇵Gunma, Maebashi, Japan
HOP Lariboisière
🇫🇷Paris, France
AZ Sint-Lucas - Campus Sint Lucas
🇧🇪Gent, Belgium
Fundación Valle de Lili
🇨🇴Cali, Colombia
Keski-Pohjanmaan keskussairaala, Kardiologian pkl, Kokkola
🇫🇮Kokkola, Finland
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim
🇧🇪Middelheim, Belgium
Brussels - HOSP Europe (Ste-Elisabeth)
🇧🇪Ukkel, Belgium
Hospital Las Higueras
🇨🇱Talcahuano, Chile
CECMI Ltda
🇨🇱Temuco, Chile
Clinical Hosp.Merkur,Clin.Internal Med,Cardiology Dep,Zagreb
🇭🇷Zagreb, Croatia
University hospital center Zagreb
🇭🇷Zagreb, Croatia
Charleroi - HOSP St-Joseph
🇧🇪Gilly, Belgium
Centro de Estudios Clinicos Barros Luco
🇨🇱Santiago, Chile
Hospital Pablo Tobón Uribe
🇨🇴Medellin, Colombia
The Geelong Hospital
🇦🇺Geelong, Victoria, Australia
Clincal Hospital Centre Rijeka
🇭🇷Rijeka, Croatia
Bonheiden - HOSP Imelda
🇧🇪Bonheiden, Belgium
Brussels-UNIV Brugmann -Horta
🇧🇪Brussel, Belgium
Sint-Niklaas - HOSP AZ Nikolaas (Campus St-Niklaas)
🇧🇪Sint-Niklaas, Belgium
MHAT"Sv.Georgi",Cardi.Clin.
🇧🇬Plovdiv, Bulgaria
MHAT "Sv. Vrach" EOOD, Cardiology Dept., Sandanski
🇧🇬Sandanski, Bulgaria
City Clin.Univ.MPHAT EOOD,Clin.of Cardiology, Sofia
🇧🇬Sofia, Bulgaria
Fundación Santa Fe de Bogotá
🇨🇴Bogotá, Colombia
University Hospital Dubrava
🇭🇷Zagreb, Croatia
Care Institute Of Medical Sciences
🇮🇳Ahmedabad, India
CHUC,EPE - Hospital Geral dos Covões
🇵🇹S. Martinho Do Bispo,Coimbra, Portugal
Fundación Clínica Abood Shaio
🇨🇴Bogotá, Colombia
Clinical Hospital Sstre Milosrdnice, Cardiology Dept, Zagreb
🇭🇷Zagreb, Croatia
Vijan Cardiac and Critical Care Centre
🇮🇳Nasik, India
Fukuoka-Higashi Med. Ctr. Fukuoka, CV
🇯🇵Fukuoka, Koga, Japan
National Hospital Organization Takasaki General Medical Center
🇯🇵Gunma, Takasaki, Japan
Tokeidai Memorial Hospital
🇯🇵Hokkaido, Sapporo, Japan
National Hospital Organization Kanazawa Medical Center
🇯🇵Ishikawa, Kanazawa, Japan
Kitasato University Hospital
🇯🇵Kanagawa, Sagamihara, Japan
Sakurabashi Watanabe Hospital
🇯🇵Osaka, Osaka, Japan
Tokyo Women's Medical University Hospital
🇯🇵Tokyo, Shinjuku-ku, Japan
Oslo Universitetssykehus HF, Ullevål sykehus
🇳🇴Oslo, Norway
Stavanger Helseforskning
🇳🇴Stavanger, Norway
Independent Public Healthcare, Dept. of Cardiology, Pulawy
🇵🇱Pulawy, Poland
John Paul II Regional Hospital, Zamosc
🇵🇱Zamosc, Poland
CHLN, EPE - Hospital de Santa Maria
🇵🇹Lisboa, Portugal
Heartcare Victoria
🇦🇺Bundoora, Victoria, Australia
StudyCor Oy
🇫🇮Jyväskylä, Finland
TYKS
🇫🇮Turku, Finland
Medanta- The Medicity
🇮🇳Gurgaon, India
Japanese Red Cross Nagoya Daini Hospital
🇯🇵Aichi, Nagoya, Japan
National Hospital Organization Hokkaido Medical Center
🇯🇵Hokkaido, Sapporo, Japan
Takahashi Hospital
🇯🇵Hyogo, Kobe, Japan
Kyoto University Hospital
🇯🇵Kyoto, Kyoto, Japan
Miyazaki Medical Association Hospital
🇯🇵Miyazaki, Miyazaki, Japan
Sayama General Clinic
🇯🇵Saitama, Sayama, Japan
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
Admiraal de Ruyter Ziekenhuis
🇳🇱Goes, Netherlands
Sørlandet sykehus HF, Avd. Arendal
🇳🇴Arendal, Norway
Oslo Universitetssykehus HF, Rikshospitalet
🇳🇴Oslo, Norway
Swissmed Vascular Sp. Z.o.o Hosp., Cardiology Dept., Gdansk
🇵🇱Gdansk, Poland
Lower Silesian Spec.Hosp.T.Marciniaka,Cardiology Dep,Wroclaw
🇵🇱Wroclaw, Poland
E-Da Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Nizam's Institute of Medical Sciences
🇮🇳Hyderabad, India
Mater Misericordiae University Hospital
🇮🇪Dublin, Ireland
Hillel Yaffe Medical Center, Hadera
🇮🇱Hadera, Israel
Hyogo Brain and Heart Center
🇯🇵Hyogo, Himeji, Japan
The Veritas Hospital
🇯🇵Hyogo, Kawanishi, Japan
Kagawa Prefectural Central Hospital
🇯🇵Kagawa, Takamatsu, Japan
Kusatsu General Hospital
🇯🇵Shiga, Kusatsu, Japan
Minamino Heart Clinic
🇯🇵Tokyo, Hachioji, Japan
Centro Especializado en Terapia Endovascular (CETEN)
🇲🇽Zapopan, Jalisco, Mexico
Scheper Ziekenhuis
🇳🇱Emmen, Netherlands
Univ. Clinic Hosp, Bialystok
🇵🇱Bialystok, Poland
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
🇵🇹Coimbra, Portugal
CHLO, EPE - Hospital de Santa Cruz
🇵🇹Lisboa, Portugal
Regional Clinical Hospital No.3, Cardiology Dept,Chelyabinsk
🇷🇺Chelyabinsk, Russian Federation
City Pokrovskiy Hospital, Cardiology Dept., Saint Petersburg
🇷🇺Saint Petersburg, Russian Federation
Slov.Ins.Crdi.Dise.,Cor.C.U.
🇸🇰Banska Bystrica, Slovakia
General Hospital Celje
🇸🇮Celje, Slovenia
Univ. Medical Center Maribor
🇸🇮Maribor, Slovenia
City Clin.Hosp.#15 n.a.O.M.Filatov,Cardiology Dept.#2,Moscow
🇷🇺Moscow, Russian Federation
King George's Hospital,
🇮🇳Seemandhra, India
Hirosaki University Hospital
🇯🇵Aomori, Hirosaki, Japan
Iwate Medical University Hospital
🇯🇵Iwate, Morioka, Japan
Omihachiman Community Medical Center
🇯🇵Shiga, Omihachiman, Japan
Nippon Medical School Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Instituto Nacional de Cardiologia Ignacio Chavez
🇲🇽Ciudad de Mexico, Mexico
Noordwest Ziekenhuisgroep
🇳🇱Alkmaar, Netherlands
Catharina Ziekenhuis
🇳🇱Eindhoven, Netherlands
UMCG
🇳🇱Groningen, Netherlands
Canisius-Wilhelmina ziekenhuis
🇳🇱Nijmegen, Netherlands
10.Military Clin.Hospital&Polyclinic
🇵🇱Bydgoszcz, Poland
University Clinical Center, Gdansk
🇵🇱Gdansk, Poland
Independent Public Clin.Hosp.#4, Cardiology Clinic,Lubilin
🇵🇱Lublin, Poland
Hospital Garcia de Orta, EPE
🇵🇹Almada, Portugal
Centro Hosp. de Leiria-Pombal
🇵🇹Leiria, Portugal
Altaiskyi Reg.Cardiologic Dispensary,Cardiology Dept,Barnaul
🇷🇺Barnaul, Russian Federation
State Budg.Healthc.Instit.Samara Reg.Clin.Cardiology Dispens
🇷🇺Samara, Russian Federation
East Slovak Inst.Cardi.Disea.
🇸🇰Kosice, Slovakia
General Hospital Izola, Cardiology Department
🇸🇮Izola, Slovenia
City Clin.Hosp#51,Moscow Healthcare Dep.X-ray surgery method
🇷🇺Moscow, Russian Federation
Shin Koga Hospital
🇯🇵Fukuoka, Kurume, Japan
Fukuyama Cardiovascular Hospital
🇯🇵Hiroshima, Fukuyama, Japan
Global Health and Medicine Ctr
🇯🇵Tokyo, Shinjuku-ku, Japan
St. Antonius ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
Universitetssykehuset Nord-Norge, Tromsø
🇳🇴Tromsø, Norway
Central Hospital of Medical Academy, Warsaw
🇵🇱Warsaw, Poland
Cent.f.Spec.Med.C.U.Cardi.Inst
🇷🇺Ekaterinburg, Russian Federation
State Autonomous Healthc Insti City Clin Hosp#7,Cardio,Kazan
🇷🇺Kazan, Russian Federation
Res.Inst.-Compl.Iss.Cardi.Dis.
🇷🇺Kemerovo, Russian Federation
State Budg.Healthc.Instit Volgograd RegClin.Cardiology Centr
🇷🇺Volgograd, Russian Federation
Nat.Instit.Cardiov.Diseas,Arryhythmias&Cardiac Pacing,Bratis
🇸🇰Bratislava, Slovakia
Chang Gung Memorial Hospital(TaoYuan)
🇨🇳Taoyuan, Taiwan
Clin.Hosp.#1na S.V.Ochapovskiy
🇷🇺Krasnodar, Russian Federation
National University Hospital
🇸🇬Singapore, Singapore
National Heart Center
🇸🇬Singapore, Singapore
Srinagarind Hospital
🇹🇭Khon Kaen, Thailand
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Taipe Veterans General Hospital
🇨🇳Taipei, Taiwan
Siriraj Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Universitätsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Princess Margaret Hospital
🇭🇰Hong Kong, Hong Kong
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong