The effects of local anesthesia with or without adrenaline on heart and circulation, for cervical conisation.
- Conditions
- Cervical conisation is done for pre-cancer disease. The procedure is done with local anesthesia and general anesthesia. Local anesthesia is given by paracervical block, and several different local anesthetics is being used including bupivacaine with and without adrenaline. Adrenaline might reduce local bleeding and reduce toxicity of bupivacaine by reducing absorption, but might affect cardiovascular function. This study will examine this effect.Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2014-004504-29-NO
- Lead Sponsor
- Helse Fonna, Haugesund Sykehus
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Women with cervical pre-cancer. Age 18-50.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 30
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Pregnancy
Feeding mother
Bad nutritional state
Infection
Treatment for hypertension
Diabetes for many years or complications
Cardiovascular disease.
Serious anemia
Cardial arrythmia
Serious liver or kidney disease
Hypersensitivity to local anesthesia of amide-type
Hypersensitivity to E 223
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method