Multi-modality Radiomics Diagnostic Model Based on DCE-MRI and Ultrasound Images for Benign and Malignant Breast Lesion Classification
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 550
- 试验地点
- 1
- 主要终点
- Accuracy of different diagnostic models
研究概览
简要总结
To develop and compare multi-modality radiomics models based on DCE-MRI, B-mode ultrasound (BMUS) and strain elastography (SE) images for classifying benign and malignant breast lesions.
详细描述
In this retrospective study,555 breast lesions from 555 patients who underwent DCE-MRI, BMUS and SE examinations were randomly divided into training (n =388) and testing (n = 167) datasets. Radiomics features were extracted from manually contoured images. The inter-class correlation coefficient (ICC), Mann-Whitney U test and the least absolute shrinkage and selection operator (LASSO) regression was applied for feature selection and radiomics signature building.Nine radiomics models including four single-modality radiomics models (DCE-3D, DCE-2D, BMUS, and SE), four multi-modality radiomics models (BMUS + SE, DCE-3D + BMUS, DCE-3D + SE, and DCE-3D+SE+BMUS), and the combination diagnostic model(clinical features and DCE-3D+SE+BMUS features) were developed and evaluated by their discrimination, calibration, and clinical usefulness.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with breast lesions underwent biopsy or surgical resection between January 1, 2018 and March 30, 2024.
排除标准
- •pathologicalresult of biopsy or surgical specimen was unavailable for the target lesion;
- •patients without DCE-MRI, BMUS and SE examinations before biopsy or surgery within one month;
- •patients hadperformed radiotherapy, chemotherapy, or breast biopsy before MRI and ultrasound examinations;
- •patients without completeDICOM data for each examination;
- •patients with poor-qualityimages.
结局指标
主要结局
Accuracy of different diagnostic models
时间窗: Immediately evaluated after the radiomcis diagnostic model was built
The accuracy of nine diagnostic models, including four single-modality radiomics models (DCE-3D, DCE-2D, BMUS, and SE), four multi-modality radiomics models (BMUS + SE, DCE-3D + BMUS, DCE-3D + SE, and DCE-3D+SE+BMUS),and the combination diagnostic model is the ratio of the sum of True Positive and True Negative to the total of True Positive, True Negative, False Positive, and False Negative.
次要结局
- Sensitivity of different diagnostic models(Immediately evaluated after the radiomcis diagnostic model was built)
研究者
Ma Zhe
Director of Ultrasound
Qianfoshan Hospital