Evaluation of a MRI-based Clinico-radiomics Model in Predicting Lymph Node Metastasis Status of Hilar Cholangiocarcinoma Patients: a Prospective Diagnostic Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hilar Cholangiocarcinoma
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Lymph node metastasis status
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This is a prospective, observational diagnostic study aiming to assess multiparametric MRI-based clinico-radiomics for identifying lymph node metastasis status in hilar cholangiocarcinoma.
Detailed Description
A preoperative tool capable of predicting lymph node metastasis status in hilar cholangiocarcinoma is lacking and urgently needed for clinical practice. This study proposes to establish and evaluate a machine-learning algorithms of multiparametric MRI-based clinico-radiomics for identifying lymph node metastasis status in hilar cholangiocarcinoma. This study will investigate the relationship between radiomic depth information and tumor biological characteristics. The study includes the construction of capable MRI-based clinico-radiomics prediction model and the validation of the prediction model.
Investigators
Eligibility Criteria
Inclusion Criteria
- •The patient must sign an informed consent form;
- •Age 18-75 years old, both male and female;
- •ECOG performance status score (PS score) 0-2;
- •Hilar cholangiocarcinoma with resectable tumor lesions;
- •Complete the upper abdomen MRI examination before treatment;
Exclusion Criteria
- •Accompanied with other primary malignant tumors;
- •Patients who have neoadjuvant chemotherapy or other tumor-targeted therapies;
- •Incomplete imaging or medical history data.
Outcomes
Primary Outcomes
Lymph node metastasis status
Time Frame: Baseline
The value of multiparametric MRI-based clinico-radiomics in predicting lymph node metastasis.