Radiomic Analysis of CT and MRI Scans for Predicting Treatment Response and Clinical Outcomes in Patients With Breast, Brain, Head-neck and Gynecological Malignancies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Sunnybrook Health Sciences Centre
- Enrollment
- 1200
- Locations
- 1
- Primary Endpoint
- Development of imaging biomarkers in predicting treatment response for breast, brain, head-neck, and gynecological malignancies
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.
Detailed Description
Imaging in oncology has widespread application with modalities like ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) having a well-established role particularly in diagnosis, staging, assessment of treatment response, and surveillance. With the applications of radiomics in oncology, the potential of imaging as a non-invasive biomarker in treatment response, as well as genotypic characterization, has been recognized. Radiomics has the potential to tailor way towards precision oncology with the development of biomarkers that can guide personalized treatments. In this study, the investigators aim at developing CT and MRI radiomic signatures as potential biomarkers to predict treatment response and clinical outcomes for patients treated with radiation having breast, brain, head and neck, and gynecological malignancies.
Investigators
Dr. Gregory Czarnota
Radiation Oncologist and Clinical Scientist
Sunnybrook Health Sciences Centre
Eligibility Criteria
Inclusion Criteria
- •Breast, head and neck, brain, and gynecological malignancies
- •Treated with radiation at Odette Cancer Centre between 2010 and 2019
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Development of imaging biomarkers in predicting treatment response for breast, brain, head-neck, and gynecological malignancies
Time Frame: 1 year
Development of imaging biomarkers in predicting treatment response
Development of imaging biomarkers in predicting clinical outcomes (survival/toxicity) for breast, brain, head-neck, and gynecological malignancies
Time Frame: 1 year
Development of imaging biomarkers in predicting clinical outcomes (survival/toxicity)