NCT06381895已完成不适用
The Efficacy of Radiomics to Predict Tumor Microenvironment Markers and Comprehensive Therapy for Bladder Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University1 个研究点 分布在 1 个国家目标入组 1,200 人开始时间: 2023年5月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Tumour-infiltrating lymphocytes (TIL)
研究概览
简要总结
The aim of this study was to develop an radiomic model based on CT images to evaluate markers of the bladder cancer microenvironment, such as TSR,TIL, and IP. Secondly, the association of the radiomic model with clinical outcomes and immunotherapy response was investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 18 years of age;
- •Performing TURB-t or RC during 2010-2022;
- •The primary lesion was located in the bladder, and the pathological diagnosis was urothelial carcinoma;
- •Complete clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records;
排除标准
- •Patients with distant metastasis;
- •Combined with other malignant tumors or malignant tumor treatment history
- •Malignant tumors of upper urinary tract;
- •Clinical information, pathological data, preoperative pelvic enhanced CT and follow-up records were missing;
- •Other situations in which the researcher considers it inappropriate to participate in this study.
结局指标
主要结局
Tumour-infiltrating lymphocytes (TIL)
时间窗: 1 year
TILs were evaluated using paraffin-embedded tumour tissue samples stained with H\&E according to established protocols.
次要结局
- overall survival(1 year)
- cancer-specific survival(1 year)
研究者
研究点 (1)
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