Radiomics for Prediction of Lymph Node Metastasis in Gastric Cancer（RPLNM）(GIPMCS-1701)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Digestive System Diseases
- Sponsor
- Nanfang Hospital, Southern Medical University
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Pathological lymph node status of every station
- Last Updated
- 8 years ago
Overview
Brief Summary
This study proposes to establish a CT radiomics-based prediction model for identifying metastasis of each station lymph nodes in gastric cancer.
Detailed Description
This is a prospective, multi-center trial conducted at 4 high-volume gastric cancer centers in China (Nanfang Hospital of Southern Medical University; Sun Yat-Sen University Cancer Center; First Affiliated Hospital, Sun Yat-Sen University; The Third Affiliated Hospital, Sun Yat-Sen University) designed to determine the predicted performance of radiomics-based prediction model for identifying metastasis of each station lymph nodes by enhanced CT for preoperative noninvasive assessment of the lymph node status in patients with gastric cancer. The study includes the construction of CT radiomics-based prediction model and the validation of the prediction model.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \>18 years;
- •Patients providing written informed consent;
- •Pathologically proven gastric cancer scheduled to preoperative enhanced abdomen CT and undergo gastrectomy with type D2 lymphadenectomy;
- •Has undergone \> 64 multi-detector row CT within 14 days prior to surgical resection; .No receipt of preoperative therapy (radiotherapy, chemotherapy or chemoradiotherapy).
Exclusion Criteria
- •Preoperative therapy (radiotherapy, chemotherapy or chemoradiotherapy);
- •Failed to receive preoperative enhanced abdomen CT or undergo gastrectomy with type D2 lymphadenectomy;
- •Inavailable pathological results for local lymph node status;
- •Inquality of CT images for feature extraction; .Patient quit.
Outcomes
Primary Outcomes
Pathological lymph node status of every station
Time Frame: Pathologic evaluation will be performed for each patient within 1 week after surgery
Pathological lymph node status of each station is defined as lymph node metastasis exist or not
Secondary Outcomes
- Survival time(Follow-up from the date of surgery to the date of death.)
- Lymph node stage (N stage)(Pathologic evaluation will be performed for each patient within 1 week after surgery)