tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder
- Conditions
- Obsessive-Compulsive Disorder
- Registration Number
- NCT06017713
- Lead Sponsor
- Centre Hospitalier Henri Laborit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria:<br><br> - Patient suffering from OCD evolving for at least 2 years diagnosed according to<br> DSM-V criteria;<br><br> - Patient with good insight, defined by a score less than or equal to 18 at the<br> threshold of delusions on the BABS (Brown Assessment of Beliefs Scale) insight<br> scale;<br><br> - Absence of a current depressive episode (MADRS score < 21) or suicidal risk (MADRS<br> score item 10 < 3);<br><br> - Absence of epileptic pathology;<br><br> - Chronic obsessive-compulsive disorder defined by a total YBOCS score > 20, or a<br> subscale score > 15;<br><br> - Drug-resistant obsessive-compulsive disorder despite treatment with:<br><br> 1. at least 2 antidepressants of the IRS type at an effective dose and for a<br> sufficient duration<br><br> 2. and/or Behavioral and Cognitive therapy for at least 1 year;<br><br> - Therapeutic stability (antidepressants) for more than 12 weeks without significant<br> improvement. This treatment, at a fixed dose, will be maintained during the study;<br><br> - Patient aged between 18 and 70 included<br><br> - Patient who has given his/her informed consent after having received written<br> information on the planned procedure;<br><br> - Patient benefiting from social security or by benefiting through a third party.<br><br>Exclusion Criteria:<br><br> - Woman of childbearing age without effective means of contraception<br> (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine<br> device, or surgical: tubal ligation, hysterectomy, total oophorectomy)<br><br> - Pregnant or nursing woman;<br><br> - Patient hospitalized under duress (SPDT, SPDRE);<br><br> - Patient under guardianship or curatorship;<br><br> - Patient with another DSM-V Axis 1 diagnosis (Schizophrenic Disorder, Bipolar<br> Disorder, Substance Abuse or Substance Dependence).<br><br>Generalized anxiety disorder, social phobia, nicotine addiction and history of major<br>depressive episodes are not exclusion criteria. Axis I comorbidity will be explored using<br>MINI 5.0.0. ;<br><br> - Patient suffering from a current depressive episode;<br><br> - Patient at risk of suicide;<br><br> - Patient with skin lesions on the scalp;<br><br> - History of head trauma;<br><br> - Patient with an intracerebral metal object<br><br> - Patient with a pacemaker;<br><br> - Presence of epileptic pathology;<br><br> - Patient in an emergency situation or unable to give personal consent
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method YBOCS scale
- Secondary Outcome Measures
Name Time Method