A management system for elderly patients with moderate to severe aortic stenosis

Phase 1

• Conditions: aortic valve stenosis in the elderly

• Registration Number: ChiCTR2400088895
• Lead Sponsor: The West China Hospital of Sichuan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

a. Patients that older than 65 years;<br>b. Clear diagnosis of moderate and severe aortic stenosis.

Exclusion Criteria

a) Have implanted artificial heart valve, artificial ring, and severe mitral calcification;<br>b) Acute coronary event occurred within 1 month, requiring revascularization but left untreated;<br>c) Hemodynamic instability, requiring cardiotonic drug support or mechanical cardiac assistance;<br>d) With infective endocarditis or other active infection;<br>e) Hypertrophic cardiomyopathy, with or without obstruction;<br>f) Echocardiography showed intracardiac thrombus or neoplasm;<br>g) Had any therapeutic or traumatic heart surgery within 30 days;<br>h) Active peptic ulceration or upper gastrointestinal bleeding within 3 months;<br>i) Cerebrovascular events within 6 months;<br>j) With an estimated life span of <12 months.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maximum pressure difference;Average pressure difference;Maximum velocity value at the stenosis;Aortic valve opening area;The inner diameter of the valve ring;left ventricular ejection fraction;interventricular septal thickness;Left ventricular ejection fraction, LVEF;Left artriumdiameter, LAD;Left ventricular end diastolic diameter, LVEDD;Right artriumdiameter, RAD;Right ventricular end diastolic diameter, RVEDD;

Secondary Outcome Measures

Name	Time	Method
The number of lobes;Classification of calcification degree;Valve thickness;Electrocardiogram data;Serological indicators;