Evaluation of Leg Muscular Activity Using MRI and 11C-acetate PET/MRI. Pilot Study
- Conditions
- Healthy
- Interventions
- Other: Magnetic Resonance combined with Positron Emission TomographyOther: Magnetic Resonance Imaging
- Registration Number
- NCT02969603
- Lead Sponsor
- Osman Ratib
- Brief Summary
The present study is conceived as a pilot study aimed to determine the efficiency of the newly available Positron Emission Tomography (PET) - Magnetic Resonance Imaging (MRI) hybrid scan technique for muscular activity evaluation, creation of anatomic images of muscle activity and resolution of metabolic activity distribution within exercising skeletal muscle.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 10
MRI exam inclusion criteria
- Male volunteer aged in the range 18 to 35 years.
- Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document.
- Volunteers that could undergo 1h15 to 1h30 immobilization (MRI exam duration in time).
PET/MRI exam inclusion criteria
- Male volunteer aged in the range 18 to 35 years.
- Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document.
- Volunteers that could undergo 1.5 to 2.0 hours immobilization (PET/MRI exam duration in time).
- Volunteers should practice regular physical activity, defined as 50 min per day (in a single session), 2 days per week of physical activity as a minimum (no maximum is fixed).
Exclusion criteria MRI exam exclusion criteria
- Pre-existing neurological or muscular lesions on the legs.
- Co morbidities impeding on the protocol comprehension or fulfilment.
- Illnesses that do not allow to lay down on an examination table.
- Pacemaker holder.
- Metal implants that would preclude MRI imaging
- Claustrophobia: Subjects will be questioned about possible discomfort with being in an enclosed space (e.g., MRI scanner). Those who report such problems will be excluded.
PET/MRI exam exclusion criteria
- Medical radiation exposure within the last five years (normal population should not be exposed to medical radiation higher or equal to 1 mSv per year).
- Pre-existing neurological or muscular lesions on the legs.
- Co morbidities impeding on the protocol comprehension or fulfilment.
- Illnesses that do not allow to lay down on an examination table.
- Pacemaker holder.
- Metal implants that would preclude MRI imaging
- Claustrophobia: Subjects will be questioned about possible discomfort with being in an enclosed space (e.g., MRI scanner). Those who report such problems will be excluded.
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy Volunteers- PET/MRI Magnetic Resonance combined with Positron Emission Tomography The volunteers will undergo a combined \[11C\]acetate PET/MRI scan Healthy volunteers- MRI Magnetic Resonance Imaging MRI scan for morphological assessment of muscle structures and anatomy
- Primary Outcome Measures
Name Time Method Assessment of musculoskeletal systems in motion though study completion, an average of 2 years an informatic visualization tool of muscles implied in leg flexion/extension combining PET and MR infomation
Distribution of acetate metabolism during exercise skeletal muscle though study completion, an average of 2 years 11C-acetate uptake (SUV and SUVratio with resting muscles) in contracting muscle, measured using muscle segmentation from MRI images
- Secondary Outcome Measures
Name Time Method Measurement of the in vivo function of the muscle though study completion, an average of 2 years correlation between 11C-acetate uptake and contractile force measures (weight and duration of exercise)
Trial Locations
- Locations (1)
Service de Medecine Nucléaire et Imagerie moléculaire- HUG
🇨🇭Geneva, Switzerland