Platelet Function During Orthotopic Liver Transplantation. An observational study.
Completed
- Conditions
- 10019654end-stage liver disease
- Registration Number
- NL-OMON32329
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
age > 17 years
first liver transplantation for liver cirrhosis
retransplantation for liver cirrhosis, more than six months after previous OLT.
Exclusion Criteria
age < 18 years
retransplantation within six months after first/last transplantation.
presence of metabolic disease
malignancies
Budd-chiari syndrome
portal vein thrombosis
use of aspirin 10 days before surgery.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Development of functional properties of vWF during and after OLT.<br /><br>Development of functional properties of platelets during and after OLT.<br /><br>Circulation of partly activated platelets during OLT (especially after<br /><br>reperfusion).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Transfusion requirements, which contains all crystalloids, colloids and blood<br /><br>products as RBCs, FFPs and Trombocytes, during the operation.<br /><br>Hepatic artery thrombosis.<br /><br>total blood loss.</p><br>