Blood Platelet Function During and After Liver Resection; an observational study

Completed

• Conditions: liver tumors; malign or benign liver tumor(s) including distant metastasis to the liver; 10019815

• Registration Number: NL-OMON39312
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Sutdy group: (extended) right hemi-hepatectomy for a malign or benign tumor including distant metastasis the liver
For the control group: pylorus preserving pancreaticoduodenectomy for pancreas head cancer.

Exclusion Criteria

1) age: patients younger than 18 and older than 65 years of age;
2) patients who use (selective)serotonin reuptake inhibitors (SSRI);
3) patients with arterial thrombosis in their medical history;
4) patients who use anticoagulants such as vitamin K antagonists, aspirin, and plavix;
5) patients with liver cirrhosis.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In this study we will examine at different timepoints during or after a liver<br /><br>resection or a PPPD:<br /><br><br /><br>a) the activation status of platelets<br /><br>b) platelet activatability<br /><br>c) the content of platelet granules, and<br /><br>d)t he activation of de novo synthesis of mitogenic proteins.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>