Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study
- Registration Number
- NCT00217165
- Lead Sponsor
- Mclean Hospital
- Brief Summary
The purpose of this study is to determine whether the amino acid taurine has effects on mood stability in bipolar disorder.
- Detailed Description
Taurine is an amino acid that has some actions similar to mood stabilizers. Taurine is widely sold as a component of over-the-counter mood enhancing agents. However, controlled studies examining the mood effects of taurine are limited. An initial study in this laboratory looked at taurine's mood effects in individuals with bipolar disorder. This follow-up study is designed to further examine taurine's effects on manic symptoms. Subjects in the current follow-up study will add taurine or placebo to their current treatment regimen. Both depressive and manic symptoms will be tracked for three months to determine whether the addition of taurine affects mood symptoms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
bipolar disorder, type I bipolar disorder, type II mania hypomania mixed manic symptoms
significant medical or psychiatric co-morbidity pregnancy or planning pregnancy current substance abuse or dependence
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo taurine cellulose active drug taurine taurine
- Primary Outcome Measures
Name Time Method Scores on standardized measures of manic and depressive symptoms (HAM-D, MADRS, YMRS) 12 weeks MADRS and YMRS
- Secondary Outcome Measures
Name Time Method Side-effect ratings, general health ratings 12 weeks SF36
Drop-outs due to medication changes 12 weeks subjects leaving study before completion
Trial Locations
- Locations (1)
McLean Hospital
🇺🇸Belmont, Massachusetts, United States