In vivo and non-invasive measurement of cytokine release in a mechanistic model of acute skin barrier disruptio

Completed

• Conditions: cytokines; inflammatory molecules; 10014982

• Registration Number: NL-OMON42792
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Age between 18 and 65 years;
Must be willing to give a written informed consent;
Must have skin type II or III (Fitzpatrick scale)

Exclusion Criteria

Pregnancy or lactation;
Atopic predisposition (i.e. history of allergic rhinitis or allergic conjunctivitis, atopic or contact dermatitis, hay fever, asthma);
Any skin disease, including possible lesions found during screening;
Skin types I, IV, V, VI;
Use of immunosuppressive drugs (NSAIDs, biological, topical or systemic corticosteroids)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study eindpoints are the levels of cytokines at baseline and at<br /><br>different time points following acute disruption of the skin barrier by means<br /><br>of tape stripping. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>