Measurement of cytokines, bloodflow and erythema after shear- force application of the skin in patients with Diabetes Mellitus

Completed

• Conditions: pressure sores; Pressure ulcer; 10012653; 10034606; 10040790

• Registration Number: NL-OMON42149
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Group A:
- Healthy volunteers
- age 40 years or older and 75 years and younger;Group B;
- patients with Diabetes Mellitus type 2 (DM) without neuropathy
- age 40 years or older and 75 years and younger
- Valk score < 4;Group C:
- Patients with DM type 2 with neuropathy
- age 40 years or older and 75 years and younger
- Valk score > 4;Group D
- Patients with (pre)- existing Charcot Ostheoarhtropathy
- age 40 years or older and 75 years and younger
- Valk score > 4;In all patients we are going to determine the Valk score to measure the amount of neuropathy in patients. The Valk score is going to be determined by someone of the research committee, or under the supervision of someone of the research committee.

Exclusion Criteria

- Trauma fore arms
- Skin diseases (psoriasis, eczema)
- NSAID use in last seven days
- Corticosteroïds
- Auto- iimune diseases
- Muscular dystrophy
- Malignancy
- Participant is unable to give informed consent
- No peripheral pulsations (a. radialis, a. dorsalis pedis, a. tibialis anterior)
- Hab1c percentage last 3 months > 11%

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. IL-1 */ totale protein ratio<br /><br>2. Bloodflow of the skin (in flux )<br /><br>3. Erythema index of the skin<br /><br>4. Cutaneous microbiome</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>