Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Phase 1
Completed
- Conditions
- Healthy Volunteers
- Interventions
- Other: polarised 3 helium
- Registration Number
- NCT01235494
- Brief Summary
To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- age 18 -70
Exclusion Criteria
- contraindication to MRI
- Resting oxygen saturation <95%
- Volunteers requiring bronchodilators less than 4 hourly
- additional respiratory diagnoses
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description polarised 3 helium polarised 3 helium inhaled gas
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does hyperpolarized 3He MRI target in lung function assessment?
How does the single breath-hold 3He MRI pulse sequence compare to standard lung imaging techniques in terms of accuracy and efficiency?
Which biomarkers are associated with optimal lung function imaging using hyperpolarized 3He gas in healthy volunteers?
What adverse events are reported with hyperpolarized 3He gas administration in MRI studies and how are they managed?
Are there combination approaches involving hyperpolarized 3He MRI and other pulmonary imaging modalities for enhanced diagnostic insights?
Trial Locations
- Locations (1)
Academic Unit of Radiology, Univeristy of Sheffield
🇬🇧Sheffield, South Yorkshire, United Kingdom
Academic Unit of Radiology, Univeristy of Sheffield🇬🇧Sheffield, South Yorkshire, United Kingdom