Asthma Exacerbation and Helium-3 MRI

Not Applicable

Withdrawn

• Conditions: Asthma Exacerbation
• Interventions: Drug: Helium-3

• Registration Number: NCT00846014
• Lead Sponsor: University of Massachusetts, Worcester

Brief Summary

The goal of this research is to use Helium-3 MRI to see the changes in airflow of the lungs at different times of an attack. These three stages are immediately after the attack, 1 month later and 4-6 months later.

Detailed Description

Asthma is a pulmonary disorder that affects millions of people each year. The exact method of exacerbation is still under some discussion. Currently there is no cure for the disorder but treatment is of a wide variety.

This study is meant to image the asthmatic lung at various time points post exacerbation. Since pulmonary imaging is currently limited to radiation techniques, this method will allow exacerbated images without the unnecessary exposure to radiation.

Study Timeline

• Study Start: 2009-01
• Study First Submitted: 2009-02-16
• Study First Submitted QC: 2009-02-17
• Study First Posted: 2009-02-18
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2012-09
• Last Update Submitted: 2012-09-18
• Last Update Posted: 2012-09-20

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Asthmatics	Helium-3	All subjects will be asthmatics that have had an exacerbation (asthma attack) no more than 48 hours before the imaging session.

Primary Outcome Measures

Name	Time	Method
Image and quantify variation in asthmatic lungs at 0, 6 months, and 12 months	1 year

Trial Locations

Locations (1)

UMASS Medical School Advanced MRI Center; 🇺🇸 Worcester, Massachusetts, United States