Effectiveness of Silk fibroin powder dressing in Superficial surgical site infections(SSI) in post laparotomy wounds when compared to Saline dressings in wound healing.

EFFECTIVENESS OF SILK FIBROIN DRESSING IN POST LAPAROTOMY PATIENTS SUPERFICIAL SURGICAL SITE INFECTIONS COMPARED TO SALINE

DRESSING IN WOUND HEALING.

PRIMARY PURPOSE : To compare the effectiveness of silk fibroin dressing and normal saline

dressing in wound healing time measured by kamal’s adaptive wound healing score.

BRIEF STUDY HYPOTHESIS :

SSI is defined as the infection that occurs within 30 days of operative procedure

or within a year of implant placement if implant is placed and the infection is

thought to be secondary to surgery. Negative pressure dressing is a new

technique in treating ssi.

Likewise silk fibroin is also emerging methods of treating SSI, proven in some

studies as an effective method to reduce wound healing time and complications

that arise due to SSI. Silk-based biomaterials stand out for its versatility and

natural biocompatibility. They are available as many formats i.e., mats,

sheets,foam,gel, powder. Silk biomaterials have been applied, e.g., in bone,

cartilage, muscular tissue.

Control of the biodegradation rate of the silk hydrogel and its high bioactivity

makes this biomaterial a choice for soft tissue engineering in comparison to other

hydrogel-based formulations, such as polydimethylsiloxane (PDMS) and

agarose(8), that show a negligible degradation due to the lack, in mammalian

tissues, of enzymes able to decompose such materials .

A randomized clinical trial proved that applying silk fibroin decreases both wound

healing time and adverse effects compared to other commercial dressings.

i.e.,100 % healed by 14 days,and 88.6 % with controlled wound dressing

improved in 19 days.

In this study I would like to test efficacy of silk fibroin in regeneration of soft tissue

and wound healing in SSI developed in laparotomy patients