Optimal Strategy of Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Due to Unprotected Left Main Coronary Artery Occlusion
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Myocardial Infarction
- Sponsor
- Shanghai Zhongshan Hospital
- Enrollment
- 480
- Locations
- 1
- Primary Endpoint
- Composite of cardiac death and recurrent myocardial infarction
- Last Updated
- 8 years ago
Overview
Brief Summary
This study will compare clinical outcomes of immediate stent implantation with deferred stent implantation(4-10days after primary angiography) for patients presented with acute myocardial infarction due to left main coronary artery occlusion.
Detailed Description
Primary percutaneous coronary intervention for patients presented with acute myocardial infarction caused by left main coronary artery occlusion is associated with significantly higher mortality and risks of major cardiac adverse events. Deferred stent implantation may improve prognosis of primary PCI through reducing distal embolization and no-reflow phenomenon. There is no randomized clinical trial focuses on the effect and outcome of deferred stent implantation on primary PCI for left main coronary artery occlusion in contrast with conventional strategy. This prospective, multicenter, randomized trial is aimed to compare immediate stenting with deferred stenting for LM-AMI with 30 centers in China involved. We hope to determine whether deferred stenting is superior to conventional strategy for primary PCI of AMI caused by left main coronary artery occlusion in improving long-term clinical outcomes and cardiac function.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of acute myocardial infarction occured within 12 hours
- •Left main coronary artery occlusion confirmed by angiography
- •Left main coronary artery occlusion (TIMI flow 0,1 or 2) confirmed by primary angiography, TIMI flow grade 3 achieved after pretreatment of thrombus aspiration or balloon dilatation
Exclusion Criteria
- •Life expectancy less than 1 years
- •Cardiogenic shock
- •Chronic kidney disease, stage 4 by KDOQI(GFR\<30ml/min)
- •Contraindications to aspirin or other anti-platelet drugs
- •Allergy to contrast agent, rapamycin or paclitaxel
- •Patients who are included in other ongoing trials
- •Pregnant female
Outcomes
Primary Outcomes
Composite of cardiac death and recurrent myocardial infarction
Time Frame: 30 days after primary angiography
Recorded in follow-up
Secondary Outcomes
- All cause death, cardiac death, recurrent myocardial infarction, target vessel revascularization(30 days after primary angiography)
- Residual stenosis of left main coronary artery(Immediately after stent implantation and 12 months after primary angiography)
- Left ventricular ejection fraction(30 days and 12 months after primary angiography)