Centralized Cord Blood Registry to Facilitate Unrelated Cord Blood Transplantation

Phase 2

Completed

Brief Summary: The National Marrow Donor Program (NMDP) has established a system for registering, matching, and tracking unrelated donor cord blood units (CBUs) and transplant outcomes. Study subjects are donors who enroll through collaborating cord blood banks. This study creates uniform collection, screening, testing and storage requirements for cord blood units. The purpose of standardization is to improve efficiency in the selection of cord blood units for transplantation.

Detailed Description: The NMDP Cord Blood registry is organized as a network of member cord blood banks and transplant centers whose interactions are managed by the NMDP's Center for Cord Blood. Banks agree to comply with uniform collection, screening, testing and storage requirements. Upon approval of membership, cord blood banks submit detailed information on each stored CBU for registration into a proprietary computer system. A transplant center, working on behalf of potential recipients, submits search requests to the NMDP and receives electronic reports detailing potentially suitable CBUs. From these reports, the transplant center selects a CBU(s) for further testing, which includes at a minimum confirmation of the CBUs Human Leukocyte Antigen (HLA) typing data. Upon final selection of the desired CBU for transplantation, arrangements are made for timely shipment of the unit to the transplant center. Following transplantation, recipient outcome data are submitted by the transplant center for addition to the study database.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
single arm	HPC, Cord Blood	HPC, Cord Blood

Primary Outcome Measures

Name	Time	Method
Study safety and efficacy for treatment for malignant and non-malignant disorders	annually

Secondary Outcome Measures

Name	Time	Method
Study relationship between HLA disparity and survival	annually

Locations (19): Gift of Life Marrow Foundation
🇺🇸
Boca Raton, Florida, United States
ITxM Cord Blood Services
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Glenview, Illinois, United States
Michigan Community Blood Centers
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Grand Rapids, Michigan, United States
Coriell - New Jersey Cord Blood Bank
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Camden, New Jersey, United States
St. Louis Cord Blood Bank
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St. Louis, Missouri, United States
J.P. McMarthy Cord Stem Cell Bank
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Detroit, Michigan, United States
Lifeforce Cryobanks
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Altamonte Springs, Florida, United States
LifeCord
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Gainesville, Florida, United States
Cleveland Cord Blood Center
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Cleveland, Ohio, United States
Texas Cord Blood Bank
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San Antonio, Texas, United States
Bonfils Cord Blood Service
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Denver, Colorado, United States
CBS - New Jersey Cord Blood bank
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Allendale, New Jersey, United States
M.D. Anderson Cord Blood Bank
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Houston, Texas, United States
StemCyte International Cord Blood Center
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Covina, California, United States
Children's Hospital of Orange County Cord Blood Bank
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Orange, California, United States
Ashley Ross Cord Blood Program
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San Diego, California, United States
Carolinas Cord Blood Bank
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Durham, North Carolina, United States
University of Colorado Cord Blood Bank
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Aurora, Colorado, United States
Puget Sound Blood Center
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Seattle, Washington, United States