The Effects of Ingesting or Rinsing Sucrose and Sucralose Solutions on Self-control, Cognitive Performance, and Blood Glucose Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions
研究概览
简要总结
The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18 - 29 kg/m2
排除标准
- •Depression
- •Type 2 diabetes
- •Phenylketonuria
- •Intake of medication known to affect glucose metabolism
- •Fasting blood glucose > 7.8 mmol/L
研究组 & 干预措施
Sucrose (50g)
A 381g blackcurrant drink (cordial and water) providing 50g of sucrose
干预措施: Ingestion of solution (Dietary Supplement)
Sucrose (50g)
A 381g blackcurrant drink (cordial and water) providing 50g of sucrose
干预措施: Rinising of solution (Dietary Supplement)
Sucralose (0.92 g sugars)
A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars
干预措施: Ingestion of solution (Dietary Supplement)
Sucralose (0.92 g sugars)
A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars
干预措施: Rinising of solution (Dietary Supplement)
结局指标
主要结局
Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions
时间窗: - 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)
Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)
次要结局
- Visual verbal learning and memory performance following self-control depletion(+ 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner))
- Attention switching performance following self-control depletion(+ 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner))
- Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions(24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner))
研究者
Prof Louise Dye
Chair of Nutrition and Behaviour
University of Leeds