The Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Performance on the paired associate recall test
研究概览
简要总结
The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women
- •70 years and older
- •Memory complaints
排除标准
- •Type I or II diabetes
- •Parkinson disease
- •MMSE < 25 (to exclude cognitively impaired subjects
- •CES-D > 16 (to exclude depressive subjects)
- •Pharmacological antidepressives or medication for dementia
- •Liver disease
研究组 & 干预措施
Placebo with sweeteners
The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink).
干预措施: Placebo (Dietary Supplement)
Drink with 100 gram of sacharose
The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice.
干预措施: sacharose (Dietary Supplement)
Drink with 50 g glucose
The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice.
干预措施: glucose (Dietary Supplement)
结局指标
主要结局
Performance on the paired associate recall test
时间窗: cognitive tests will start 15 minutes after ingestion of the intervention product
Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed
次要结局
- Mood(within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink))
- Blood glucose response(from baseline till 90 minutes after consuming the drink)
- Plasma insulin levels(At t= -15 minutes, before consuming the test drink)
研究者
Lisette de Groot
PhD
Wageningen University