The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

Not Applicable

Completed

• Conditions: Blood Glucose Response; Cognitive Performance; Self-control
• Interventions: Dietary Supplement: Ingestion of solution; Dietary Supplement: Rinising of solution

• Registration Number: NCT02075333
• Lead Sponsor: University of Leeds

Brief Summary

The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-02-26
• Study First Submitted QC: 2014-02-28
• Study First Posted: 2014-03-03
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-11
• Last Update Posted: 2016-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• BMI 18 - 29 kg/m2

Exclusion Criteria

• Dementia
• Depression
• Type 2 diabetes
• Phenylketonuria
• Intake of medication known to affect glucose metabolism
• Fasting blood glucose > 7.8 mmol/L

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sucralose (0.92 g sugars)	Ingestion of solution	A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars
Sucralose (0.92 g sugars)	Rinising of solution	A 381g blackcurrant drink (cordial and water) providing 0.92g of natural sugars
Sucrose (50g)	Ingestion of solution	A 381g blackcurrant drink (cordial and water) providing 50g of sucrose
Sucrose (50g)	Rinising of solution	A 381g blackcurrant drink (cordial and water) providing 50g of sucrose

Primary Outcome Measures

Name	Time	Method
Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	- 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)

Secondary Outcome Measures

Name	Time	Method
Visual verbal learning and memory performance following self-control depletion	+ 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Attention switching performance following self-control depletion	+ 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)	A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels

Trial Locations

Locations (1)

Human Appetite Research Unit (University of Leeds); 🇬🇧 Leeds, United Kingdom