Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

Not Applicable

Completed

• Conditions: Mental Health; Cognition; Memory; Attention

• Registration Number: NCT01427231
• Lead Sponsor: Wageningen University

Brief Summary

The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08
• Study First Submitted: 2011-08-26
• Study First Submitted QC: 2011-08-31
• Study First Posted: 2011-09-01
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-20
• Last Update Posted: 2012-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• Men and women
• 70 years and older
• Memory complaints

Exclusion Criteria

• Type I or II diabetes
• Parkinson disease
• MMSE < 25 (to exclude cognitively impaired subjects
• CES-D > 16 (to exclude depressive subjects)
• Pharmacological antidepressives or medication for dementia
• Liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Performance on the paired associate recall test	cognitive tests will start 15 minutes after ingestion of the intervention product	Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed

Secondary Outcome Measures

Name	Time	Method
Mood	within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink)	Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests.
Blood glucose response	from baseline till 90 minutes after consuming the drink	Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes.
Plasma insulin levels	At t= -15 minutes, before consuming the test drink	One venapunction will be carried out at baseline to measure plasma insulin levels.

Trial Locations

Locations (1)

Wageningen University; 🇳🇱 Wageningen, Gelderland, Netherlands