Effect of perioperative individualized systolic pressure management and mean arterial pressure management on the incidence of postoperative vital organ dysfunction in elderly patients undergoing major abdominal surgery

Phase 1

Recruiting

Conditions: perioperative hypotension

Registration Number: ChiCTR2400088763

Lead Sponsor: Zhongda Hospital affiliated to Southeast University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

1.The age ranged from 65 to 85 years,no gender limit 2.Major abdominal surgery is planned under general anesthesia, with an expected operation time of more than 2 hours and an expected hospital stay of at least 3 days 3.American Standards Association (ASA) classification: ASA class I to ? 4. After comprehensively understanding of the objectives and importance of this research,patients voluntarily participated in this clinical trial and informed consent was obtained

Exclusion Criteria

1.Chronic kidney disease (glomerular filtration rate <30ml/min/1.73m^2 or end-stage renal disease requiring renal replacement therapy) 2.Severe chronic obstructive pulmonary disease, acute respiratory distress syndrome with hypoxemia 3.Acute or decompensated heart failure, acute coronary syndrome, severe arrhythmia, valvular disease with severe hemodynamic disturbances 4.The preoperative diagnosis was dementia, cognitive impairment, or a history of psychiatric illness 5.The preoperative diagnosis was sepsis or shock state with continuous infusion of vasoactive agents 6.Surgery required for controlled hypotension(e.g., hepatectomy) 7.Minor abdominal surgery (e.g., laparoscopic cholecystectomy) 8.General anesthesia was combined with spinal anesthesia 9.Additional medical conditions were determined to be ineligible for inclusion by researchers 10.Participated in other clinical studies in the past 3 months

Study & Design

Study Type: Interventional study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of postoperative vital organ dysfunction;

Secondary Outcome Measures

Name	Time	Method
The number and duration of intraoperative hypotension (defined as less than 20% of the target value);The number and duration of intraoperative hypertension (defined as 20% above the target value);incidence of individual organ dysfunction;Incidence of systemic inflammatory response syndrome (SIRS) at 1, 2, and 7 days after surgery;SOFA, Glasgow, 3D-CAM score and Kdigo stage at 1, 2 and 7 days after surgery;Incidence of vital organ dysfunction within 30 days after surgery;The incidence of surgery-related complications within 30 days after surgery;