Von Willebrand Factor and Protein C Ratio in Graft Function After Liver Transplant

• Conditions: Liver Transplant; Complications
• Interventions: Procedure: LT

• Registration Number: NCT04324255
• Lead Sponsor: Asan Medical Center

Brief Summary

In liver cirrhosis (LC),the activity of von Willebrand factor (vWF)-cleaving enzyme ADAMTS13 is reduced in LC patients and consequent progression of liver injury. Remarkably, it has been reported that a severe vWF/ADAMTS13 imbalance develops during liver transplantation (LT) and persists even after LT. Such changes are thought to contribute to postoperative thrombotic complications, which may lead to early adverse events of thrombotic microangiopathy after living-donor LT (LDLT). We investigated whether vWFPCR could predict EAD or graft failure following LT and compared it with FVIIIPCR, procoagulant, such as vWF and FVIII and anticoagulant, such as PC.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2016-12-30
• Status Verified: 2020-03
• Study First Submitted: 2020-03-21
• Study First Submitted QC: 2020-03-26
• Last Update Submitted: 2020-03-26
• Study First Posted: 2020-03-27
• Last Update Posted: 2020-03-27
• Study Completion: 2020-04-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1199

Inclusion Criteria

patients who underwent LT

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Exclusion Criteria

deceased-donor liver transplant, and insufficient data, ABO-incompatible LT

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
High ratio	LT	Liver recipient with high preoperative von Willbrand factor-to-protein C ratio
Low ratio	LT	Liver recipient with low preoperative von Willbrand factor-to-protein C ratio

Primary Outcome Measures

Name	Time	Method
Early allograft dysfunction	within 7 days after surgery	Immediate liver graft function

Secondary Outcome Measures

Name	Time	Method
Graft failure	90 days	re-liver transplantation or death, whichever was first
intensive care unit stay	until the day of patients moving to general wards, through study completion, an average of 1 year	days of intensive care unit stay after liver transplant

Trial Locations

Locations (1)

Asan Medical center; 🇰🇷 Seoul, Korea, Republic of