Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease

Terminated

• Conditions: Coronary Artery Disease
• Interventions: Other: Blood draws

• Registration Number: NCT00905294
• Lead Sponsor: University College Cork

Brief Summary

The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-05-19
• Study First Submitted QC: 2009-05-19
• Study First Posted: 2009-05-20
• Study Start: 2009-08
• Primary Completion: 2010-08
• Study Completion: 2010-08
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-17
• Last Update Posted: 2013-06-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA)
• Planned percutaneous coronary intervention during admission

Exclusion Criteria

• Recent history (< 6 months) of an acute coronary syndrome (other than current admission) or stroke
• Recent history (< 6 months) of major surgery, trauma or thromboembolic event
• Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months
• Current evidence of infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
coronary artery disease	Blood draws	Subjects with coronary artery disease undergoing percutaneous coronary intervention

Primary Outcome Measures

Name	Time	Method
relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels	change from baseline to after percutaneous coronary intervention	Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study

Trial Locations

Locations (2)

Cork University Hospital; 🇮🇪 Cork, Ireland

Beaumont Hospital; 🇮🇪 Dublin, Ireland