Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease
Terminated
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT00905294
- Lead Sponsor
- University College Cork
- Brief Summary
The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA)
- Planned percutaneous coronary intervention during admission
Exclusion Criteria
- Recent history (< 6 months) of an acute coronary syndrome (other than current admission) or stroke
- Recent history (< 6 months) of major surgery, trauma or thromboembolic event
- Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months
- Current evidence of infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels change from baseline to after percutaneous coronary intervention Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Cork University Hospital
🇮🇪Cork, Ireland
Beaumont Hospital
🇮🇪Dublin, Ireland
Cork University Hospital🇮🇪Cork, Ireland