Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer
- Registration Number
- NCT00878709
- Lead Sponsor
- Puma Biotechnology, Inc.
- Brief Summary
The purpose of this study is to investigate whether neratinib can further reduce the risk of recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment with trastuzumab.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 2840
- Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.
- Been treated for early breast cancer with standard of care duration of trastuzumab.
- Could have been treated neoadjuvantly but have not reached pathologic complete response.
- Positive clinical and radiologic assessments for local or regional recurrence of disease at the time of study entry.
- History of heart disease.
- Corrected QT (QTc) interval >0.45 seconds
- History of gastrointestinal disease with diarrhea as the major symptom.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Neratinib neratinib 240 mg orally daily for one year Placebo placebo orally daily for one year
- Primary Outcome Measures
Name Time Method Invasive Disease-free Survival (iDFS) in Neratinib Arm Compared to Placebo Arm at Year 2 From randomization until time of event up to 2 years Invasive disease-free survival time is defined as the time from date of randomization until the first disease recurrence of the following events: invasive ipsilateral breast tumor recurrence, invasive contralateral breast cancer, local/regional invasive recurrence, distant recurrence and death from any cause.
Kaplan-Meier Estimates of Invasive Disease-free Survival (iDFS) at Year 2 by Treatment Arms From randomization until time of event up to 2 years
- Secondary Outcome Measures
Name Time Method Overall Survival (OS) Randomization until death due to any cause (up to 119 Months) OS was defined as the time from randomization to death due to any cause, censored at the last date known alive.
Disease-free Survival Including Ductal Carcinoma in Situ (DFS-DCIS) in Neratinib Arm Compared to Placebo Arm at Year 2 From randomization until time of event up to 2 years Disease-free survival including DCIS time is defined as the time from date of randomization until the first occurrence of DCIS or an iDFS event (an iDFS event including invasive ipsilateral breast tumor recurrence, invasive contralateral breast cancer, local/regional invasive recurrence, or distant recurrence and death from any.
Kaplan-Meier Estimates of Disease-free Survival Including Ductal Carcinoma in Situ (DFS-DCIS) at Year 2 by Treatment Arms From randomization until time of event up to 2 years Distant Disease-free Survival (DDFS) in Neratinib Arm Compared to Placebo Arm at Year 2 From randomization until time of event up to 2 years Distant disease-free survival time is defined as the time from date of randomization until the first occurrence of distant recurrence or death from any cause.
Kaplan-Meier Estimates of Distant Disease-free Survival (DDFS) at Year 2 by Treatment Arms From randomization until time of event up to 2 years Percentage of Participants With Time to Distant Recurrence (TTDR) Event in Neratinib Arm Compared to Placebo Arm at Year 2 From randomization until time of event up to 2 years Percentage of Participants with TTDR events is reported. TTDR is defined as the time from date of randomization until the first occurrence of distant recurrence or death from breast cancer.
Kaplan-Meier Estimates of Time to Distant Recurrence (TTDR) Survival at Year 2 by Treatment Arms From randomization until time of event up to 2 years Central Nervous System Recurrence in Neratinib Arm Compared to Placebo Arm at Year 2 From randomization until time of event up to 2 years CNS recurrence is defined as the time from randomization to CNS as the first distant recurrence. Competing events include distant recurrence at other sites as the first distant recurrence and death from any cause prior to distant recurrence.
Cumulative Incidence of Central Nervous System Recurrence (CNS) at Year 2 From randomization until time of event up to 2 years Cumulative incidence of Central Nervous System Recurrence (CNS) is estimated by Gray's method (Gray,1988).
Trial Locations
- Locations (485)
Mercy Hospital Oncology/Hematology Center
🇺🇸Portland, Maine, United States
Cancer Specialists of South Texas, P.A.
🇺🇸Corpus Christi, Texas, United States
University Hospitals, Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
MetroHealth Medical Center
🇺🇸Cleveland, Ohio, United States
Texas Oncology - Memorial City
🇺🇸Houston, Texas, United States
Medicus Alliance Clinical Research Org., Inc.
🇺🇸Houston, Texas, United States
The Methodist Hospital Breast Center
🇺🇸Houston, Texas, United States
Central Indiana Cancer Centers
🇺🇸Indianapolis, Indiana, United States
Hematology Oncology of Indiana
🇺🇸Indianapolis, Indiana, United States
University Hospital of Patras
🇬🇷Rio Patras, Greece
The Christ Hospital Cancer Center
🇺🇸Cincinnati, Ohio, United States
Hospital Universitario de Canarias
🇪🇸La Laguna, Santa Cruz De Tenerife, Spain
Helen Diller Family University of California San Francisco Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
San Francisco Oncology Associates
🇺🇸San Francisco, California, United States
Nashville Breast Center
🇺🇸Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Cancer Care Centers of South Texas
🇺🇸San Antonio, Texas, United States
Utah Cancer Specialists
🇺🇸Salt Lake City, Utah, United States
Arizona Oncology Associates, PC - HAL
🇺🇸Phoenix, Arizona, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Næstved Sygehus
🇩🇰Naestved, Denmark
Birmingham Hematology and Oncology Associates, LLC
🇺🇸Birmingham, Alabama, United States
Azienda Ospedaliera San Luigi Gonzaga
🇮🇹Orbassano (TO), Italy
Azienda Ospedaliero-Universitaria Pisana
🇮🇹Pisa, Italy
Istituto Oncologico del Mediterraneo
🇮🇹Viagrande (CT), Italy
Jichi Medical University Hospital
🇯🇵Tochigi, Japan
Frauenklinik der J.W. Goethe-Universitaet
🇩🇪Frankfurt am Main, Germany
Universitaetsfrauenklinikum Schleswig-Holstein
🇩🇪Luebeck, Germany
Universitaetsklinikum Magdeburg A.oe.R.
🇩🇪Magdeburg, Germany
Praxis Gynaekologie Arabella Muenchen
🇩🇪Muenchen, Germany
Oncologianova GmbH
🇩🇪Recklinghausen, Germany
St. Marienhospital Vechta
🇩🇪Vechta, Germany
Gemeinschaftspraxis fuer Haematologie und Onkologie
🇩🇪Westerstede, Germany
Pole Hospitalier Mutualiste
🇫🇷Saint-Nazaire, France
Hospital Puerta de Hierro-Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital De Basurto
🇪🇸Bilbao, Vizcaya, Spain
Hospital Universitario Vall D´Hebron
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Spain
Hospital Universitario de Guadalajara
🇪🇸Guadalajara, Spain
Hospital Clinico Universitario Virgen de La Victoria
🇪🇸Malaga, Spain
Hospital Virgen de la Salud
🇪🇸Toledo, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Fundacion Instituto Valenciano de Oncologia
🇪🇸Valencia, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Provincial de Zamora
🇪🇸Zamora, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Skanes Onkologiska Kliniken
🇸🇪Lund, Sweden
Spital STS AG
🇨🇭Thun, Switzerland
Cancer Center of Central Connecticut
🇺🇸Southington, Connecticut, United States
Cedars-Sinai Medical Group
🇺🇸Beverly Hills, California, United States
Piedmont Cancer Institute
🇺🇸Atlanta, Georgia, United States
Arizona Oncology Associates, PC - NAHOA
🇺🇸Sedona, Arizona, United States
Breastlink Medical Group
🇺🇸Long Beach, California, United States
Broward General Medical Center
🇺🇸Fort Lauderdale, Florida, United States
Northeast Arkansas Clinic
🇺🇸Jonesboro, Arkansas, United States
Gynecologic Oncology Associates
🇺🇸Newport Beach, California, United States
California Cancer Care
🇺🇸Greenbrae, California, United States
Redwood Regional Medical Group
🇺🇸Santa Rosa, California, United States
Ventura County Hematology-Oncology Specialists
🇺🇸Oxnard, California, United States
Beaver Medical Group, L.P.
🇺🇸Highland, California, United States
Washington Cancer Institute at Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
Glendale Adventist Medical Center Cancer Services
🇺🇸Glendale, California, United States
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
North Broward Medical Center
🇺🇸Deerfield Beach, Florida, United States
Lakeland Regional Cancer Center
🇺🇸Lakeland, Florida, United States
Florida Cancer Affiliates - Ocala
🇺🇸Ocala, Florida, United States
El Paso Cancer Treatment Center - West
🇺🇸El Paso, Texas, United States
Oncology and Hematology of West Broward
🇺🇸Tamarac, Florida, United States
Advocate Medical Group
🇺🇸Niles, Illinois, United States
Florida Cancer Specialists, P.L.
🇺🇸Saint Petersburg, Florida, United States
Washington University School of Medicine Siteman Cancer Center
🇺🇸Saint Louis, Missouri, United States
Northern Michigan Hematology/Oncology
🇺🇸Petoskey, Michigan, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Harry and Jeanette Weinberg Cancer Center
🇺🇸Baltimore, Maryland, United States
Augusta Oncology Associates (ACORN), P.C.
🇺🇸Augusta, Georgia, United States
Phoebe Cancer Center
🇺🇸Albany, Georgia, United States
Portneuf Medical Center
🇺🇸Pocatello, Idaho, United States
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Midwestern Regional Medical Center
🇺🇸Zion, Illinois, United States
Dwight David Eisenhower Army Medical Center
🇺🇸Fort Gordon, Georgia, United States
Orchard Research, LLC
🇺🇸Skokie, Illinois, United States
Medical Arts Associates, Ltd
🇺🇸Moline, Illinois, United States
Ashland-Bellefonte Cancer Center
🇺🇸Ashland, Kentucky, United States
Quincy Medical Group, Cancer Center at Blessing Hospital
🇺🇸Quincy, Illinois, United States
Hematology-Oncology Clinic
🇺🇸Baton Rouge, Louisiana, United States
North Mississippi Hematology and Oncology Associates, Ltd.
🇺🇸Tupelo, Mississippi, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Medical Specialty Associates
🇺🇸Grand Rapids, Michigan, United States
Oncology and Hematology Specialist
🇺🇸Mountain Lakes, New Jersey, United States
Jersey Shore University Medical Center
🇺🇸Neptune, New Jersey, United States
Massachusetts General Hospital - Gillette Center
🇺🇸Boston, Massachusetts, United States
Central Maine Healthcare Corp
🇺🇸Lewiston, Maine, United States
Montana Cancer Specialists
🇺🇸Missoula, Montana, United States
Thompson Cancer Survival Center
🇺🇸Knoxville, Tennessee, United States
Bend Memorial Clinic
🇺🇸Bend, Oregon, United States
Center for Oncology Research
🇺🇸Dallas, Texas, United States
Aurora BayCare Medical Center
🇺🇸Green Bay, Wisconsin, United States
Cancer Care Northwest-North
🇺🇸Spokane, Washington, United States
Texas Oncology P.A.
🇺🇸Sugar Land, Texas, United States
Inova Schar Cancer Institute
🇺🇸Fairfax, Virginia, United States
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
🇧🇷Porto Alegre, RS, Brazil
District Dispensary for Oncology Diseases Internal Unit- Plovdiv EOOD, Ist
🇧🇬Plovdiv, Bulgaria
Centre Hospitalier Regional de La Citadelle
🇧🇪Liege, Belgium
Saint Barnabas Health Care System
🇺🇸Livingston, New Jersey, United States
Great Plains Regional Medical Center
🇺🇸North Platte, Nebraska, United States
Southeast Nebraska Hematology & Oncology Consultants, PC
🇺🇸Lincoln, Nebraska, United States
North Utah Associates
🇺🇸Ogden, Utah, United States
East Texas Medical Center Cancer Institute
🇺🇸Tyler, Texas, United States
Temple University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
AZ Zusters van Barmhartigheid
🇧🇪Ronse, Belgium
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Az. St. Jan
🇧🇪Brugge, Belgium
C.H.U. Ambroise Paré
🇧🇪Mons, Belgium
AZ Nikolaas
🇧🇪Sint Niklaas, Belgium
Sint-Elisabethziekenhuis
🇧🇪Turnhout, Belgium
VZW Jesseziekenhuis - Campus Virga Jesse
🇧🇪Hasselt, Belgium
Jan Yperman Ziekenhuis
🇧🇪Ieper, Belgium
AZ Groeninge ampus Maria's Voorzienigheid (MV) Oncologisch Centrum
🇧🇪Kortrijk, Belgium
CHU de Liège - Domaine Universitaire du Sart Tilman
🇧🇪Liège, Belgium
Iron Cancer Care South Brisbane
🇦🇺South Brisbane, Queensland, Australia
Royal Melbourne Hospital
🇦🇺Melbourne, Victoria, Australia
Affinity Research Limited
🇧🇸Nassau, Bahamas
Hollywood Private Hospital
🇦🇺Nedlands, Western Australia, Australia
OLVZ Medische Oncologie
🇧🇪Aalst, Belgium
Sydney West Cancer Trials Centre
🇦🇺Sydney, New South Wales, Australia
Center for Integrative Cancer Medicine, PA
🇺🇸El Paso, Texas, United States
Virginia Cancer Specialists, PC
🇺🇸Fairfax, Virginia, United States
University Health Network, Princess Margaret Hospital
🇨🇦Toronto, Ontario, Canada
BC Cancer Agency
🇨🇦Vancouver, British Columbia, Canada
Aalborg Sygehus
🇩🇰Aalborg, Denmark
Humber River Regional Hospital - Church Street Site
🇨🇦Weston, Ontario, Canada
Interdistrict Dispensary for Oncology Diseases
🇧🇬Varna, Bulgaria
Peking Union Medical College Hospital of Chinese Academy of Medical Sciences
🇨🇳Beijing, China
District Dispensary for Oncology Diseases Internal Unit- Plovdiv EOOD, Second
🇧🇬Plovdiv, Bulgaria
Jack Ady Cancer Centre
🇨🇦Lethbridge, Alberta, Canada
Rigshospitalet
🇩🇰Copenhagen, Denmark
Herlev Hospital
🇩🇰Herlev, Denmark
Odense Universitetshospital
🇩🇰Odense C, Denmark
Roskilde University Hospital
🇩🇰Roskilde, Denmark
Sygehus Sonderjylland
🇩🇰Sonderborg, Denmark
CancerCare Manitoba
🇨🇦Winnipeg, Manitoba, Canada
District Dispensary for Oncology Diseases Internal Unit- Sofia EOOD
🇧🇬Sofia, Bulgaria
Specialised Hospital of Active Treatment in Oncology
🇧🇬Sofia, Bulgaria
General Hospital Varazdin
🇭🇷Varazdin, Croatia
Klinicki bolnicki centar "Sestre Milosrdnice"
🇭🇷Zagreb, Croatia
University Hospital Center Zagreb
🇭🇷Zagreb, Croatia
Oncologos del Occidente
🇨🇴Pereira, Risaralda, Colombia
Tianjin Cancer Hospital
🇨🇳Tianjin, China
Hillerod Hospital
🇩🇰Hillerod, Denmark
Regionshospital Viborg
🇩🇰Viborg, Denmark
Institut Curie, Département d'Oncologie Médicale
🇫🇷Paris, France
Centre François Baclesse
🇫🇷Caen, France
Cancer Hospital, Chinese Academy of Medical Sciences
🇨🇳Beijing, China
Masarykuv Onkologicky ustav
🇨🇿Brno, Czechia
Nemocnice Jihlava
🇨🇿Jihlava, Czechia
Centre Hospitalier de Montluçon
🇫🇷Clermont-Ferrand, France
Oncologie department, Hopital albert Michalon
🇫🇷Grenoble, France
Chinese People's Liberation Army General Hospital
🇨🇳Beijing, China
The Hospital Affiliated Academy Military Medical Science, Chinese People's
🇨🇳Beijing, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Sun Yat-Sen University Cancer Center
🇨🇳Guangzhou, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, China
Aarhus University Hospital
🇩🇰Aarhus C, Denmark
Sydvestjysk Sygehus
🇩🇰Esbjerg, Denmark
Vejle Sygehus
🇩🇰Vejle, Denmark
R.S. McLaughlin Durham Regional Cancer Centre
🇨🇦Oshawa, Ontario, Canada
Centre Hospitalier Affilie Universitaire de Quebec Hopital du St-Sacrement
🇨🇦Quebec, Canada
Administradora Country S.A-Clinica del Country
🇨🇴Bogota, Colombia
University Hospital Centre Osijek, Department of Radiotherapy and Oncology
🇭🇷Osijek, Croatia
Southern Medical University Nanfang Hospital
🇨🇳Guangzhou, China
Oncomedica S.A. IMAT
🇨🇴Monteria, Cordoba, Colombia
Centre Rene Gauducheau
🇫🇷Saint Herblain, Cedex, France
C.H.U. De Bordeaux Saint Andre
🇫🇷Bordeaux, Cedex, France
Sozialstiftung Bamberg Klinik fuer Haematologie und Internistische Onkologie
🇩🇪Bamberg, Germany
Hopital de Versailles
🇫🇷Le Chesnay, France
Hopital Saint Louis
🇫🇷Paris Cedex 10, France
Hopital La Pitie-Salpetriere
🇫🇷Paris cedex 13, France
Staedtische Kliniken Frankfurt am Main-Hoechst Frauenklinik
🇩🇪Frankfurt am Main, Germany
Praxisklinik Krebsheilkunde fuer Frauen
🇩🇪Berlin, Germany
Centre Henri Becquerel
🇫🇷Rouen, Cedex 1, France
Service d'Oncologie et de Radiotherapie, Polyclinique Francheville, 38
🇫🇷Perigueux, France
Centre Georges Francois Leclerc
🇫🇷Dijon, France
Nationales Centrum fuer Tumorerkrankungen
🇩🇪Heidelberg, Germany
Klinikum St. Georg/Franziskus, Abteilung fuer Senologie
🇩🇪Georgsmarienhuette, Germany
Klinikum Kempten - Oberallgaeu
🇩🇪Kempten, Germany
CHU Strasbourg
🇫🇷Strasbourg, France
Onkologische Praxis
🇩🇪Augsburg, Germany
MTV Abts & Partner Kiel
🇩🇪Kiel, Germany
Universitaetsfrauenklinik Tuebingen
🇩🇪Tuebingen, Germany
Institute de Cancerologie de la Loire
🇫🇷Saint Priest en Jarez, France
Institut Gustave Roussy
🇫🇷Villejuif, France
Praxis für interdisziplinaere Onkologie & Haematologie GbR
🇩🇪Freiburg, Germany
Klinikum Oldenburg GmbH
🇩🇪Oldenburg, Germany
Kreiskrankenhaus Hameln, Onkologische Ambulanz
🇩🇪Hameln, Germany
Universitaetsklinikum Duesseldorf, Frauenklinik
🇩🇪Duesseldorf, Germany
CHU Bretonneau Centre Henry Kaplan
🇫🇷Tours, France
University Hospital of Heraklion
🇬🇷Heraklion, Creete, Greece
University General Hospital of Alexandroupoli, Department of Medical Oncology
🇬🇷Alexandroúpoli, Greece
Fachpraxis fuer Innere Medizin
🇩🇪Muenchen, Germany
Klinikum der Johannes-Gutenberg-Universitaet
🇩🇪Mainz, Germany
Klinik und Poliklinik fuer
🇩🇪Muenchen, Germany
Azienda Ospedaliera Universitaria "Policlinico Vittorio Emanuele"
🇮🇹Catania, Italy
Azienda Ospedaliera San Gerardo
🇮🇹Monza, Italy
IRCCS Istituto Oncologico Veneto di Padova
🇮🇹Padova, Italy
Ospedale SS Trinita
🇮🇹Sora (FR), Italy
National Cancer Center Hospital East
🇯🇵Chiba, Japan
Chiba Cancer Center
🇯🇵Chiba, Japan
Ospedale San Pietro Fatebenefratelli
🇮🇹Roma, Italy
Marienhospital Witten
🇩🇪Witten, Germany
Hippokratio General Hospital of Athens
🇬🇷Athens, Greece
Hippokration Hospital Athens
🇬🇷Athens, Greece
Azienda Ospedaliera S. Maria
🇮🇹Terni, Italy
Hiroshima City Hospital
🇯🇵Hiroshima, Japan
Hyogo Cancer Center
🇯🇵Hyogo, Japan
Kurume Daiichi Social Insurance Hospital
🇯🇵Fukuoka, Japan
Queen Mary Hospital, Department of Medicine, Blk K
🇭🇰Hong Kong, Hong Kong
Universita Campus Bio-Medico
🇮🇹Roma, Italy
Bekes M. Kepviselotest. Pandy Kalman Korhaz, Megyei Onkol. Kp., Klin. Onkol. es Sugartherapias Oszt.
🇭🇺Gyula, Hungary
Bacs-Kiskun Megyei Korhaz Onkoradiologiai Kozpont
🇭🇺Kecskemet, Hungary
Orszagos Onkologiai Intezet "B" Belgyogyaszati osztaly
🇭🇺Budapest, Hungary
Shizuoka Cancer Center
🇯🇵Shizuoka, Japan
Veszprem Megyei Csolnoky Ferenc Korhaz Nonprofit Zrt.
🇭🇺Veszprem, Hungary
Fovarosi Onkormanyzat Szent Imre Korhaz
🇭🇺Budapest, Hungary
Rambam Health care campus, Oncology institute
🇮🇱Haifa, Israel
Presidio Ospedaliero di Summa - Antonio Perrino
🇮🇹Brindisi, Italy
Fondazione per la Ricerca e la Cura dei Tumori Tommaso Campanella
🇮🇹Catanzaro, Italy
Unita' Operativa Complessa Oncologia Medica, A.O.R.N. "Cardarelli"
🇮🇹Napoli, Italy
Sir Paul Boffa Hospital
🇲🇹Floriana, Malta
Centrum Onkologii im. prof. Franciszka Łukaszczyka
🇵🇱Bydgoszcz, Poland
Niigata Cancer Center Hospital 2-15-3
🇯🇵Niigata, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Hokkaido, Japan
Samsung Medical Center
🇰🇷Seoul, Korea, Korea, Republic of
Azienda Ospedaliera San Giuseppe Moscati
🇮🇹Avellino, Italy
Fondazione Giovanni Pascale
🇮🇹Napoli, Italy
Azienda Ospedaliera Bianchi Melacrino Morelli
🇮🇹Reggio Calabria, Italy
Ospedale Belcolle Viterbo
🇮🇹Viterbo, Italy
Borsod-Abauj-Zemplen M. Korhaz es Egyetemi Okt. K., Klin. Onk., Sugarterapias es Kozp. Szuro Centrum
🇭🇺Miskolc, Hungary
National Hospital Organization Osaka National Hospital
🇯🇵Osaka, Japan
Kaplan Medical Center, Department of Oncology
🇮🇱Rehovot, Israel
Hospital de Barbastro
🇪🇸Barbastro, Huesca, Spain
Kyoto University Hospital
🇯🇵Kyoto, Japan
Oncologia Medica A, Istituti Fisioterapici Ospitalieri
🇮🇹Roma, Italy
Haga Ziekenhuis
🇳🇱Den Haag, Netherlands
Maxima Medisch Centrum
🇳🇱Eindhoven, Netherlands
Tokai University Hospital
🇯🇵Kanagawa, Japan
Osaka Medical Center for Cancer and Cardiovascular Diseases
🇯🇵Osaka, Japan
Osaka University Hospital
🇯🇵Osaka, Japan
Saitama Cancer Center
🇯🇵Saitama, Japan
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Wojewodzki Oddzial
🇵🇱Jelenia Gora, Poland
Olsztynski Osrodek Onkologiczny Kopernik Sp. z o.o.
🇵🇱Olsztyn, Poland
Hakuaikai Medical Corporation Sagara Hospital
🇯🇵Kagoshima, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka, Japan
Ziekenhuis Amstelland
🇳🇱Amstelveen, Netherlands
Gelre ZH
🇳🇱Apeldoorn, Netherlands
Auckland Hospital
🇳🇿Auckland, New Zealand
Amphia Ziekenhuis - Interne Geneeskunde
🇳🇱Breda, Netherlands
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
🇯🇵Tokyo, Japan
The Hospital of Lithuanian University of Health Sciences Kauno klinikos Oncology and Haematology Clinic
🇱🇹Kaunas, Lithuania
Oncology Institute of Vilnius University
🇱🇹Vilnius, Lithuania
Seoul National University Hospital, Department of Internal Medicine
🇰🇷Seoul, Korea, Republic of
University Clinic for Radiotherapy and Oncology
🇲🇰Skopje, North Macedonia
Bialostockie Centrum Onkologii im. M. Sklodowskiej- Curie w Bialymstoku
🇵🇱Bialystok, Poland
Institutul Oncologic "Prof. Dr. Ion Chiricuta"
🇷🇴Cluj-Napoca, Cluj, Romania
Institute of Oncology and Radiology of Serbia
🇷🇸Belgrade, Serbia
National Cancer Centre Singapore
🇸🇬Singapore, Singapore
Poliklinika ADUS
🇸🇰Poprad, Slovakia
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
Zaklad Opieki Zdrowotnej MSWiA z Warminsko - Mazurskim Centrum Onkologii w
🇵🇱Olsztyn, Poland
Szpital Wojewodzki im. Sw. Lukasza Samodzielny Publiczny Zaklad Opieki
🇵🇱Tarnow, Poland
SC Oncolab S.R.L.
🇷🇴Craiova, Dolj, Romania
Oddelenie radioterapie a onkologie
🇸🇰Kosice, Slovakia
Hospital Universitari Son Espases
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Hospital Universitario Fundacion de Alcorcon
🇪🇸Alcorcon, Madrid, Spain
Hospital Mutua de Terrassa
🇪🇸Terrassa, Barcelona, Spain
Hospital Clinic i Provincial de Barcelona
🇪🇸Barcelona, Spain
Hospital San Pedro de Alcantara
🇪🇸Caceres, Spain
Consorcio Hospitalario Provincial de Castellon
🇪🇸Castellon, Spain
Complejo Hospitalario de Jaen
🇪🇸Jaen, Spain
Hospital Universitari Arnau de Vilanova de Lleida
🇪🇸Lleida, Spain
Hospital Universitario Insular de Gran Canaria
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Universitario Nuestra Señora de Candelaria
🇪🇸Santa Cruz de Tenerife, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Onkologiska Kliniken
🇸🇪Lund, Sweden
Uludag Universitesi Tip Fakultesi
🇹🇷Gorukle/Bursa, Turkey
Istanbul Universitesi Istanbul Tip Fakultesi
🇹🇷Capa/Istanbul, Turkey
Hirslanden Medical Center Tumor Center
🇨🇭Aarau, Switzerland
Kantonsspital Olten-Medizinische Onkologie
🇨🇭Olten, Switzerland
St James's University Hospital
🇬🇧Leeds, United Kingdom
Kaohsiung Medical University Chung-Ho memorial Hospital
🇨🇳Kaohsiung, Taiwan
Gazi Universitesi Tip Fakultesi
🇹🇷Besevler/Ankara, Turkey
Ege Universitesi Tip Fakultesi
🇹🇷Bornova/Izmir, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi, Ic Hastaliklari Anabilim Dali
🇹🇷Cerrahpasa/Istanbul, Turkey
Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi
🇹🇷Demetevler/Ankara, Turkey
Dokuz Eylul Universitesi Tip Fakultesi
🇹🇷Inciralti/Izmir, Turkey
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Gaziantep Universitesi
🇹🇷Sehitkamil/Gaziantep, Turkey
Queens Hospital
🇬🇧Burton-on-Trent, Staffs, United Kingdom
National Taiwan University Hospital
🇨🇳Taipei TOC, Taiwan
Betsi Cadwaladr University Health Board
🇬🇧Rhyl, Denbighshire, United Kingdom
Christie Hospital
🇬🇧Manchester, United Kingdom
St. Bartholomew's Hospital
🇬🇧London, United Kingdom
Norfolk & Norwich University Hospitals
🇬🇧Norwich, United Kingdom
Weston Park Hospital
🇬🇧Sheffield, United Kingdom
University Hospitals of Leicester
🇬🇧Leicester, United Kingdom
Nottingham City Hospital
🇬🇧Nottingham, United Kingdom
Singleton Hospital
🇬🇧Swansea, United Kingdom
Charing Cross Hospital, Department Of Medical Oncology
🇬🇧London, United Kingdom
Southend University Hospital
🇬🇧Westcliff-on-Sea, United Kingdom
Capitol Comprehensive Cancer Care Clinic
🇺🇸Jefferson City, Missouri, United States
Anniston Oncology
🇺🇸Anniston, Alabama, United States
Institut Onkologie a Reahabilitace na Plesi
🇨🇿Nova Ves pod Plesi, Czechia
Fakultni Nemocnice v Motole
🇨🇿Praha, Czechia
Multiscan s. r. o.
🇨🇿Pardubice, Czechia
Ashford Cancer Centre Research
🇦🇺Kurralta Park, South Australia, Australia
The Queen Elizabeth Hospital
🇦🇺Adelaide, South Australia, Australia
North Adelaide Oncology Calvary Hospital North Adelaide
🇦🇺North Adelaide, South Australia, Australia
The Western Hospital
🇦🇺Melbourne, Victoria, Australia
Northwest Cancer Specialist, P.C.
🇺🇸Portland, Oregon, United States
Kaiser Permanente Northwest Region Oncology Hematology
🇺🇸Portland, Oregon, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Rutland Regional Medical Center
🇺🇸Rutland, Vermont, United States
Minnesota Oncology Hematology, PA
🇺🇸Minneapolis, Minnesota, United States
Park Nicollet Institute
🇺🇸Saint Louis Park, Minnesota, United States
Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
Jabboury Foundation for Cancer Research, Inc.
🇺🇸Houston, Texas, United States
Florida Cancer Research Institute
🇺🇸Plantation, Florida, United States
Springfield Clinic, LLP
🇺🇸Springfield, Illinois, United States
Hematology Oncology Associates of Treasure Coast
🇺🇸Port Saint Lucie, Florida, United States
ICO de Girona - Hospital Universitario de Girona Dr. Josep Trueta
🇪🇸Girona, Spain
Hematology Oncology Associates
🇺🇸Loxahatchee Groves, Florida, United States
Facharzt fuer Frauenheilkunde
🇩🇪Hannover, Germany
Stronach Regional Cancer Centre at Southlake
🇨🇦Newmarket, Ontario, Canada
Mid-Florida Hematology & Oncology Centers, PA
🇺🇸Orange City, Florida, United States
Cancer Care & Hematology Specialists of Chicagoland
🇺🇸Niles, Illinois, United States
Simmons Cancer Institute
🇺🇸Springfield, Illinois, United States
Trinitas Comprehensive Cancer Center
🇺🇸Elizabeth, New Jersey, United States
Mercy Medical Research Institute
🇺🇸Springfield, Missouri, United States
Marienhospital
🇩🇪Aachen, Germany
Texas Oncology Cancer Care and Research Center
🇺🇸Waco, Texas, United States
Pius-Hospital Oldenburg
🇩🇪Oldenburg, Germany
CHU Paul Brousse
🇫🇷Villejuif, France
Arizona Oncology Associates
🇺🇸Tucson, Arizona, United States
Facey Medical Group
🇺🇸Mission Hills, California, United States
Ronald Yanagihara, M.D.
🇺🇸Gilroy, California, United States
Hematology Oncology, PC
🇺🇸Stamford, Connecticut, United States
Connecticut Oncology and Hematology
🇺🇸Torrington, Connecticut, United States
The Cancer Prevention and Treatment Center
🇺🇸Soquel, California, United States
Innovative Medical Research of South Florida, Inc.
🇺🇸Aventura, Florida, United States
University Cancer Institute, LLC
🇺🇸Boynton Beach, Florida, United States
Midwest Center for Hematology/Oncology
🇺🇸Joliet, Illinois, United States
Cancer Care Specialists of Illinois, Decatur Memorial Hospital Clinical Research
🇺🇸Decatur, Illinois, United States
North Shore Cancer Research Associates
🇺🇸Skokie, Illinois, United States
Orchard Healthcare Research, Inc.
🇺🇸Skokie, Illinois, United States
Community Hospital
🇺🇸Munster, Indiana, United States
Purchase Cancer Group
🇺🇸Paducah, Kentucky, United States
Medical Oncology & Hematology Mercy Medical Center
🇺🇸Baltimore, Maryland, United States
York Hospital Oncology Treatment Center
🇺🇸York, Maine, United States
Alliance Hematology Oncology, PA Carroll County Cancer Center
🇺🇸Westminster, Maryland, United States
University of Massachusetts Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
Cancer and Hematology Centers of Western Michigan
🇺🇸Grand Rapids, Michigan, United States
St. Joseph's Oncology
🇺🇸Saint Joseph, Missouri, United States
The Center for Cancer and Hematologic Disease
🇺🇸Cherry Hill, New Jersey, United States
Cooper University Hospital
🇺🇸Voorhees, New Jersey, United States
The Valley Hospital, Luckow Pavilion
🇺🇸Paramus, New Jersey, United States
ProHealth Care Associates
🇺🇸Lake Success, New York, United States
NYU Clinical Cancer Center
🇺🇸New York, New York, United States
Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
Raleigh Hematology Oncology Associates Cancer Centers of North Carolina
🇺🇸Raleigh, North Carolina, United States
Duke University Medical Center Medical Oncology
🇺🇸Durham, North Carolina, United States
Mid Dakota Clinic, PC
🇺🇸Bismarck, North Dakota, United States
Mercy Physicians of Oklahoma
🇺🇸Oklahoma City, Oklahoma, United States
Samaritan Hematology & Oncology Consultants
🇺🇸Corvallis, Oregon, United States
Providence Cancer Center Oncology and Hematology Care - Westside
🇺🇸Portland, Oregon, United States
Signal Point Hematology/Oncology, Inc.
🇺🇸Middletown, Ohio, United States
Willamette Valley Cancer Institute and Research Center
🇺🇸Springfield, Oregon, United States
Oncology-Hematology of Lehigh Valley, PC
🇺🇸Bethlehem, Pennsylvania, United States
Pinnacle Health Cancer Center Community Campus
🇺🇸Harrisburg, Pennsylvania, United States
Sweeney-Melenyser Pavillion
🇺🇸Monongahela, Pennsylvania, United States
Abington Hematology Oncology Associates, Inc
🇺🇸Willow Grove, Pennsylvania, United States
Guthrie Clinic, Limited
🇺🇸Sayre, Pennsylvania, United States
Pawtuket Memorial Hospital
🇺🇸Pawtucket, Rhode Island, United States
University Hematology/Oncology Associates PLLC
🇺🇸Chattanooga, Tennessee, United States
South Carolina Cancer Specialists
🇺🇸Hilton Head Island, South Carolina, United States
Santee Hematology Oncology
🇺🇸Sumter, South Carolina, United States
Avera Medical Oncology and Hematology - Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
McLeod Oncology and Hematology Associates
🇺🇸Florence, South Carolina, United States
Cookeville Regional Cancer Center
🇺🇸Cookeville, Tennessee, United States
The Jones Clinic, PC
🇺🇸Germantown, Tennessee, United States
Coastal Bend Cancer Center
🇺🇸Corpus Christi, Texas, United States
Texas Oncology, P.A.
🇺🇸Paris, Texas, United States
South Texas Institute of Cancer
🇺🇸Corpus Christi, Texas, United States
Frauenarzt-Zentrum-Zehlendorf
🇩🇪Berlin, Germany
Texas Oncology - Baylor Charles A. Sammons Cancer Center
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center Simmons Cancer Center
🇺🇸Dallas, Texas, United States
Texas Oncology
🇺🇸Tyler, Texas, United States
South Texas Oncology & Hematology
🇺🇸San Antonio, Texas, United States
Cascade Cancer Center
🇺🇸Kirkland, Washington, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
Southwestern Vermont Regional Cancer Center
🇺🇸Bennington, Vermont, United States
Northwest Medical Specialties PLLC
🇺🇸Tacoma, Washington, United States
Wenatchee Valley Medical Center
🇺🇸Wenatchee, Washington, United States
West Virginia University Mary Babb Randolph Cancer Center
🇺🇸Morgantown, West Virginia, United States
Wheeling Hospital
🇺🇸Wheeling, West Virginia, United States
Cliniques Universitaires de Bruxelles
🇧🇪Bruxelles, Belgium
Wheaton Franciscan Cancer Care-All Saints
🇺🇸Racine, Wisconsin, United States
AZ Damiaan - Site Sint-Jozef
🇧🇪Oostende, Belgium
Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
London Regional Cancer Program
🇨🇦London, Ontario, Canada
C.H.U.M. - Hopital Notre-Dame, Departement d'Oncologie
🇨🇦Montreal, Quebec, Canada
CSSS Alphonse-Desjardins
🇨🇦Quebec, Canada
Hopital du Sacre-Coeur de Montreal
🇨🇦Montreal, Quebec, Canada
Centre Oscar Lambret
🇫🇷Lille, France
Clinique Sainte Anne Centre de Radiothérapie
🇫🇷Strasbourg, France
Onkologische Schwerpunktpraxis
🇩🇪Heidelberg, Germany
Luisenkrankenhaus
🇩🇪Duesseldorf, Germany
Universitaetsklinikum Duesseldorf
🇩🇪Düsseldorf, Germany
Facharzt fuer Frauenheilkunde und Geburtshilfe
🇩🇪Erfurt, Germany
Onkologische Gemeinschaftspraxis Frankfurt
🇩🇪Frankfurt am Main, Germany
Klinik für Gynaekologie und gyn. Onkologie
🇩🇪Wiesbaden, Germany
General Hospital of Chania Ag. Georgios
🇬🇷Chania, Crete, Greece
University General Hospital of Larissa
🇬🇷Larissa, Greece
Kaposi Mor Oktato Korhaz, Onkologiai Centrum
🇭🇺Kaposvar, Hungary
Department of Clinical Oncology, Tuen Mun Hospital
🇭🇰Hong Kong, Hong Kong
Euromedica General Clinic
🇬🇷Thessaloniki, Greece
Josa Andras Oktatokorhaz Egeszsegugyi Szolgaltato Nonprofit Kft. / Onkoradiologiai Osztaly
🇭🇺Nyiregyhaza, Hungary
Soroka University MC, Department of Oncology
🇮🇱Beer Sheva, Israel
Sheba Medical Center, Oncology Institute Tel Hashomer
🇮🇱Tel Hashomer, Israel
Kumamoto Municipal Hospital
🇯🇵Kumamoto, Japan
Ospedale Treviglio e Caravaggio, UO Oncologia Medica
🇮🇹Treviglio, BG, Italy
Aichi Cancer Center
🇯🇵Aichi, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Ehime, Japan
Kanagawa Cancer Center
🇯🇵Kanagawa, Japan
Tokyo Metropolitan Cancer and Infectious disease Center Komagome Hp
🇯🇵Tokyo, Japan
National Cancer Center, Center for Breast Cancer
🇰🇷Gyeonggi-do, Korea, Republic of
Korea University Anam Hospital, Department of Oncology/Hematology
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Orbis Medisch Centrum
🇳🇱Sittard-Geleen, Netherlands
Vlietland Ziekenhuis
🇳🇱Schiedam, Netherlands
Clínica Vista Alegre / Unidad de Investigacion
🇵🇪Surco, Lima, Peru
Uniwersyteckie Centrum Kliniczne w Gdansku
🇵🇱Gdansk, Poland
Centrum Medyczne Ostrobramska Niepubliczny Zaklad Opieki Zdrowotnej "Magodent"
🇵🇱Warszawa, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w
🇵🇱Krakow, Poland
Hospital de Torrevieja
🇪🇸Torrevieja, Alicante, Spain
Spitalul Universitar de Urgenta Bucuresti
🇷🇴Bucuresti, Romania
Interna onkologicka klinika
🇸🇰Bratislava, Slovakia
Clinical centre Nis
🇷🇸Nis, Serbia
ICO de Barcelona - Hospital Duran i Reynals, Hospitalet de Llobregat Consorci Sanitari de Terrassa
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Puerta del Mar
🇪🇸Cadiz, Spain
Centro Oncologico de Galicia
🇪🇸A Coruna, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Madrid Norte Sanchinarro. Centro Integral Oncologico Clara Campal
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Kantonsspital Baden
🇨🇭Baden, Switzerland
Hacettepe Universitesi Tip Fakultesi
🇹🇷Sihhiye/Ankara, Turkey
Desert Hematology Oncology Medical Group, Inc
🇺🇸Rancho Mirage, California, United States
Summit Medical Group
🇺🇸Morristown, New Jersey, United States
Albert Einstein Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Crescent City Research Consortium, LLC
🇺🇸Marrero, Louisiana, United States
NorthEast Oncology Associates Carolinas Medical Center NorthEast
🇺🇸Concord, North Carolina, United States
Hanover Medical Specialists, PA
🇺🇸Wilmington, North Carolina, United States
Gettysburg Cancer Center
🇺🇸Gettysburg, Pennsylvania, United States
Perelman Center for Advanced Medicine
🇺🇸Philadelphia, Pennsylvania, United States
Klinik fuer Gynaekologie und Geburtshilfe
🇩🇪Offenbach, Germany
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
Francisco Gonzalez MD PA
🇺🇸Columbia, South Carolina, United States
Straub Clinic & Hospital
🇺🇸Honolulu, Hawaii, United States
Semmelweis Egyetem Radiologiai és Onkoterapias Klinika
🇭🇺Budapest, Hungary
Chang Gung Medical Foundation, Linkou Branch
🇨🇳Kwei-Shan, Taoyuan, Taiwan
Queen Mary Hospital, Department of Clinical Oncology, Professorial Block
🇭🇰Hong Kong, Hong Kong
Szpital Morski im. PCK Gdynskie Centrum Onkologii Oddzial Chemioterapii
🇵🇱Gdynia, Poland
Cancer Centers of Florida
🇺🇸Orlando, Florida, United States
M.D. Anderson Cancer Center Orlando
🇺🇸Orlando, Florida, United States
Medical University of South Carolina Hollings Cancer Center
🇺🇸Charleston, South Carolina, United States
Charleston Hematology Oncology Associates, PA
🇺🇸Charleston, South Carolina, United States
Florida Cancer Specialists and Research Institute
🇺🇸Gainesville, Florida, United States
Eastchester Center for Cancer Care
🇺🇸Bronx, New York, United States
Nucleo de Especialidades Oncológicas
🇲🇽Guadalajara, Jalisco, Mexico
Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Consorci Sanitari de Terrassa
🇪🇸Terrassa, Barcelona, Spain
Guy's Hospital
🇬🇧London, United Kingdom
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States
UNIMED Medical Institute, Comprehensive Centre for Breast Diseases
🇭🇰Hong Kong, Wanchai, Hong Kong
Queen Mary Hospital, Department of Medicine
🇭🇰Hong Kong, Hong Kong