To see if probiotics will help in preventing development of ventilator associated pneumonia
Phase 4
- Conditions
- Health Condition 1: J17- Pneumonia in diseases classified elsewhere
- Registration Number
- CTRI/2023/11/059910
- Lead Sponsor
- I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All critically ill patients of at least 18 years of age who were mechanically ventilated with an endotracheal tube for more than 48 hours.
Exclusion Criteria
Previous history of immunosuppression, prosthetic cardiac valve or valvular graft, rheumatic fever, recent gastroesophageal or intestinal injury/surgery, tracheostomy, patient refusal. Patient having pregnancy/pneumonia currently, severe multiple organ failure with Acute Physiology and Chronic Health Evaluation (APACHE) II score of more than or equal to 25 & Mechanical ventilation for more than 72 hours prior to enrolment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of probiotics on preventing VAP, and other clinically important outcomes in the intensive care unit (ICU)Timepoint: 14 days
- Secondary Outcome Measures
Name Time Method Duration of Mechanical Ventilation <br/ ><br>Timepoint: 31 days;Incidence of constipation/diarrhea <br/ ><br> <br/ ><br>Timepoint: 14 days;Length of stay in ICUTimepoint: 31 days