NCT00771355
Terminated
Not Applicable
In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vitiligo
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- To describe characteristic features seen by confocal microscopy of several pigmentary disorders.
- Status
- Terminated
- Last Updated
- 15 years ago
Overview
Brief Summary
This is a pilot study to evaluate the findings of the Reflectance Confocal Microscopy when performed in cutaneous pigmentary disorders, such as vitiligo, melasma, post-inflammatory hyper-pigmentation and hypo-pigmentation. Confocal Microscopy is a recent diagnostic technique that has been used for observation of skin conditions that affect the superficial layers of the skin.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects 20-70 years of age.
- •Clinical diagnosis of vitiligo, melasma, post-inflammatory hypo or depigmentation or post-inflammatory hyperpigmentation.
- •Willing and able to understand and sign informed consent.
- •Able to complete study and comply with study procedures.
Exclusion Criteria
- •Use of topical therapies such as corticosteroids, protopic, hydroquinone and azelaic acid within the past 2 months.
- •Use of light therapy such as narrow-band-UVB, PUVA or laser within the past 2 months.
- •Intake of medications that can cause pigmentary changes within the past year. Examples are:
- •Antimalarials (chloroquine, hydroxychloroquine)
- •Chemotherapeutics (bleomycin, busulfan, doxorubicin, daunorubicin, fluorouracil, cyclophosphamide, and carmustine)
- •Heavy metals (gold, silver, bismuth, and mercury)
- •Tetracyclines (including minocycline, doxycycline)
- •Amiodarone
- •Azidothymidine
- •Clofazimine
Outcomes
Primary Outcomes
To describe characteristic features seen by confocal microscopy of several pigmentary disorders.
Time Frame: study visit
Study Sites (1)
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